Animal and human studies with the mitochondria-targeted antioxidant MitoQ
Animal and human studies with the mitochondria-targeted antioxidant MitoQ
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DOI：
10.1111/j.1749-6632.2010.05627.x
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发表时间：
2010-01-01
期刊：
影响因子：
--
通讯作者：
Murphy, Michael P.
中科院分区：
文献类型：
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作者：
Smith, Robin A. J.;Murphy, Michael P.
As mitochondrial oxidative damage contributes to a wide range of human diseases, antioxidants designed to be accumulated by mitochondria in vivo have been developed. The most extensively studied of these mitochondria-targeted antioxidants is MitoQ, which contains the antioxidant quinone moiety covalently attached to a lipophilic triphenylphosphonium cation. MitoQ has now been used in a range of in vivo studies in rats and mice and in two phase II human trials. Here, we review what has been learned from these animal and human studies with MitoQ.
