Role of heparan sulfatases in ovarian and breast cancer.
Role of heparan sulfatases in ovarian and breast cancer.
复制标题
DOI：
--
复制
发表时间：
2013
影响因子：
5.3
通讯作者：
A. Khurana;Daniah T Beleford;Xiaoping He;J. Chien;V. Shridhar
中科院分区：
文献类型：
--
作者：
A. Khurana;Daniah T Beleford;Xiaoping He;J. Chien;V. Shridhar
内硫酸酯酶HSulf-1和-2（也称为Sulf 1和-2）代表调节肝素结合生长因子信号传导的酶家族。乙酰肝素硫酸酯酶1（HSulf-1）和乙酰肝素硫酸酯酶2（HSulf-2）是两种重要的6-O内硫酸酯酶，其去除或编辑存在于高度硫酸化的HS上的N-葡糖胺的6-O硫酸酯残基。硫酸乙酰肝素酶的改变已经在几种癌症类型的背景下被鉴定。许多癌症类型在转录水平上表现出HSulfs表达的增加或减少。具体而言，发现HSulf-1在早期卵巢肿瘤、肝细胞癌和转移性乳腺癌患者中下调。发现HSulf-2在导管原位癌和浸润性导管癌中上调，而关于HSulf-2在卵巢癌不同阶段表达的信息有限。本文综述了硫酸酯酶在卵巢癌和乳腺癌中的重要作用，包括肿瘤血管生成、化疗耐药、细胞凋亡、生长因子信号转导、缺氧和转移等。这些最近的发现增加了对这些硫酸盐编辑酶的重要理解。
Endosulfatases HSulf-1 and -2 (also referred to as Sulf1 and -2) represent a family of enzymes that modulate heparin binding growth factor signaling. Heparan sulfatase 1 (HSulf-1) and heparan sulfatase 2 (HSulf-2) are two important 6-O endosulfatases which remove or edit 6-O sulfate residues of N-glucosamine present on highly sulfated HS. Alteration of heparan sulfatases have been identified in the context of several cancer types. Many cancer types either exhibit increased or decreased HSulfs expression at the transcript levels. Specifically, HSulf-1 was found to be downregulated in early-stage ovarian tumors, hepatocellular carcinoma, and metastatic breast cancer patients. HSulf-2 was found to be upregulated in ductal carcinoma in situ and invasive ductal carcinoma, whereas limited information is present about HSulf-2 expression in different stages of ovarian cancers. Here, we review the important role of these sulfatases play in ovarian and breast cancers in terms of tumorigenesis such as angiogenesis, chemoresistance, apoptosis, growth factor signaling, hypoxia and metastasis. These recent discoveries have added significant understanding about these sulfate editing enzymes.