BMP 7 is required for nephrogenesis, eye development, and skeletal patterning
BMP 7 is required for nephrogenesis, eye development, and skeletal patterning
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DOI：
10.1111/j.1749-6632.1996.tb56247.x
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发表时间：
1996-01-01
期刊：
影响因子：
--
通讯作者：
Bradley, A
中科院分区：
文献类型：
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作者：
Karsenty, G;Luo, GB;Bradley, A
总之，BMP-7 缺陷小鼠的产生提供了额外的证据，证明该生长因子家族调节许多形态发生过程，包括但不限于骨骼发育。特别是，我们的实验表明，BMP 7 是肾小球形成的早期诱导剂，并且它是骨骼图案化和晶状体形成所必需的。我们的结果不仅证明 BMP 7 参与发育过程中多个器官的分化，而且还提出了这样的假设：Bmp 7 基因本身或遗传途径中的突变可能是导致肾小球形成受损的几种人类遗传疾病的原因。
In summary, the generation of BMP-7-deficient mice has provided additional evidence that this family of growth factors regulate many morphogenetic processes including but not limited to skeletal development. In particular our experiments demonstrate that BMP 7 acts as an early inducer of glomeruli formation, and that it is required for skeletal patterning and lens formation. Our results not only demonstrate that BMP 7 is involved in the differentiation of several organs during development, but also raise the hypothesis that mutations in the Bmp 7 gene itself or in the genetic pathway could be responsible for several human genetic diseases in which glomerulus formation is impaired.