Quinolone antibiotics inhibit eucaryotic DNA polymerase α and β, Terminal deoxynucleotidyl Transferase but not DNA ligase
Quinolone antibiotics inhibit eucaryotic DNA polymerase α and β, Terminal deoxynucleotidyl Transferase but not DNA ligase
复制标题
喹诺酮类抗生素抑制真核 DNA 聚合酶 α 和 β、末端脱氧核苷酸转移酶，但不抑制 DNA 连接酶
DOI：
10.1016/0006-291x(84)90744-7
复制
发表时间：
1984
影响因子：
3.1
通讯作者：
J. David
中科院分区：
文献类型：
--
作者：
R. Rusquet;M. Bonhommet;J. David
DNA polymerases α and β, Terminal deoxynucleotidyl Transferase and DNA ligases from chicken thymus were purified to homogeneity. Quinolone antibiotics (nalidixic acid, oxolinic acid and pefloxacin) known to inhibit DNA replication were tested for their effects on these enzymes. DNA ligase activity was not affected by the three drugs. DNA polymerases α and β were inhibited by competitive mechanisms. Surprisingly, Terminal deoxynucleotidyl Transferase was strongly inhibited by the three compounds and more efficiently by nalidixic acid. The significance of these results is discussed in terms of the possible involvement of the enzymes in the respective DNA replication and repair processes.
