Angiogenesis: a new theory for endometriosis
Angiogenesis: a new theory for endometriosis
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DOI：
10.1093/humupd/4.5.736
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发表时间：
1998-09-01
影响因子：
13.3
通讯作者：
Wingfield, M
中科院分区：
文献类型：
--
作者：
Healy, DL;Rogers, PAW;Wingfield, M
子宫内膜过度血管生成被认为是子宫内膜异位症发病机制中的一个重要环节。本文综述了子宫内膜异位症患者子宫内膜增殖、植入和生长能力增强的假说。结果还表明，细胞粘附分子整合素α（V）β（3）表达在子宫内膜异位症的妇女子宫内膜血管与正常妇女相比，两者合计，这些结果提供了证据，子宫内膜异位症的妇女子宫内膜血管生成增加时，与正常受试者相比。子宫内膜异位症是血管生成性疾病家族中的一员，其他血管生成性疾病包括实体瘤、类风湿性关节炎、银屑病和糖尿病视网膜病变。过度的子宫内膜血管生成提示了旨在抑制血管生成的新的治疗子宫内膜异位症的药物。
Excessive endometrial angiogenesis is proposed as an important mechanism in the pathogenesis of endometriosis, Evidence is reviewed for the hypothesis that the endometrium of women with endometriosis has an increased capacity to proliferate, implant and grow in the peritoneal cavity, Data is summarized indicating that the endometrium of patients with endometriosis shows enhanced endothelial cell proliferation. Results are also reviewed indicating that the cell adhesion molecule integrin alpha(v)beta(3) is expressed in more blood vessels in the endometrium of women with endometriosis when compared with normal women, Taken together, these results provide evidence for increased endometrial angiogenesis in women with endometriosis when compared with normal subjects. Endometriosis is one of the family of angiogenic diseases, Other angiogenic diseases include solid tumours, rheumatoid arthritis, psoriasis and diabetic retanopathy, Excessive endometrial angiogenesis suggests novel new medical treatments for endometriosis aimed at the inhibition of angiogenesis.