Genetic Epidemiology of Psoriasis.
Genetic Epidemiology of Psoriasis.
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DOI：
10.1007/s13671-013-0066-6
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发表时间：
2014-03
影响因子：
1.6
通讯作者：
Liao, Wilson
中科院分区：
文献类型：
--
作者：
Gupta, Rashmi;Debbaneh, Maya G;Liao, Wilson
牛皮癣是一种慢性、炎症性、免疫介导的皮肤病，全世界的患病率为 0-11.8%。它与许多心血管、代谢和自身免疫性疾病合并症有关。牛皮癣是一种多因素疾病，受遗传和环境因素的影响。其遗传基础早已通过双胞胎研究和家族聚类建立起来。许多研究已表明牛皮癣与 HLA-Cw6 等位基因之间的关联。最近的全基因组关联研究已经确定了大量与牛皮癣相关的其他基因。其中许多基因调节先天性和适应性免疫系统。这些发现表明免疫系统失调可能在牛皮癣的发病机制中发挥重要作用。在本文中，我们回顾了牛皮癣的临床和遗传流行病学，并简要描述了疾病的发病机制。
Psoriasis is a chronic, inflammatory, immune-mediated skin condition with a prevalence of 0-11.8% across the world. It is associated with a number of cardiovascular, metabolic, and autoimmune disease co-morbidities. Psoriasis is a multifactorial disorder, influenced by both genetic and environmental factors. Its genetic basis has long been established through twin studies and familial clustering. The association of psoriasis with the HLA-Cw6 allele has been shown in many studies. Recent genome-wide association studies have identified a large number of other genes associated with psoriasis. Many of these genes regulate the innate and adaptive immune system. These findings indicate that a dysregulated immune system may play a major role in the pathogenesis of psoriasis. In this article, we review the clinical and genetic epidemiology of psoriasis with a brief description of the pathogenesis of disease.