The Concise Guide to PHARMACOLOGY 2015/16: G protein-coupled receptors.
The Concise Guide to PHARMACOLOGY 2015/16: G protein-coupled receptors.
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DOI：
10.1111/bph.13348
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发表时间：
2015-12
影响因子：
7.3
通讯作者：
CGTP Collaborators
中科院分区：
文献类型：
--
作者：
Alexander SP;Davenport AP;Kelly E;Marrion N;Peters JA;Benson HE;Faccenda E;Pawson AJ;Sharman JL;Southan C;Davies JA;CGTP Collaborators
简明药理学指南2015/16提供了超过1750种人类药物靶标的关键特性及其药理学的简明概述，以及药物靶标及其配体的开放获取知识库（www.guidetopharmacology.org）的链接，该知识库提供了靶标和配体特性的更详细视图。完整的内容可以在http://onlinelibrary.wiley.com/doi/10.1111/bph.13348/full上找到。G蛋白偶联受体是指南中划分的八大药理学靶点之一，其他靶点包括：配体门控离子通道、电压门控离子通道、其他离子通道、核激素受体、催化受体、酶和转运蛋白。这些都提出了命名指南和最佳药理学工具的摘要信息，以及进一步阅读的关键参考和建议。《简明指南》以横向格式出版，以便对相关目标进行比较。它是2015年底的当代材料的浓缩版，在网站www.guidetopharmacology.org上提供了更详细的信息并不断更新，取代了之前的《受体和通道指南》和《2013/14年药理学简明指南》中提供的数据。它与NC-IUPHAR一起生产，并在适当的情况下为人类药物靶标提供官方IUPHAR分类和命名。它整合了先前在IUPHAR-DB和GRAC中分别策划和显示的信息，并提供了一个永久的，可引用的，时间点的记录，该记录将在数据库更新后继续存在。
The Concise Guide to PHARMACOLOGY 2015/16 provides concise overviews of the key properties of over 1750 human drug targets with their pharmacology, plus links to an open access knowledgebase of drug targets and their ligands (www.guidetopharmacology.org), which provides more detailed views of target and ligand properties. The full contents can be found at http://onlinelibrary.wiley.com/doi/10.1111/bph.13348/full. G protein‐coupled receptors are one of the eight major pharmacological targets into which the Guide is divided, with the others being: ligand‐gated ion channels, voltage‐gated ion channels, other ion channels, nuclear hormone receptors, catalytic receptors, enzymes and transporters. These are presented with nomenclature guidance and summary information on the best available pharmacological tools, alongside key references and suggestions for further reading. The Concise Guide is published in landscape format in order to facilitate comparison of related targets. It is a condensed version of material contemporary to late 2015, which is presented in greater detail and constantly updated on the website www.guidetopharmacology.org, superseding data presented in the previous Guides to Receptors & Channels and the Concise Guide to PHARMACOLOGY 2013/14. It is produced in conjunction with NC‐IUPHAR and provides the official IUPHAR classification and nomenclature for human drug targets, where appropriate. It consolidates information previously curated and displayed separately in IUPHAR‐DB and GRAC and provides a permanent, citable, point‐in‐time record that will survive database updates.