Marine-derived myxobacteria of the suborder Nannocystineae: An underexplored source of structurally intriguing and biologically active metabolites.
Marine-derived myxobacteria of the suborder Nannocystineae: An underexplored source of structurally intriguing and biologically active metabolites.
复制标题
DOI：
10.3762/bjoc.12.96
复制
发表时间：
2016
影响因子：
2.7
通讯作者：
König GM
中科院分区：
文献类型：
--
作者：
Dávila-Céspedes A;Hufendiek P;Crüsemann M;Schäberle TF;König GM
粘细菌以其产生最有趣的次级代谢产物的能力而闻名。直到最近，只有陆生粘细菌才成为研究的焦点。然而，在这篇综述中，我们讨论了海洋来源的粘细菌，这是特别有趣的，由于他们相对较新的发现，并由于事实上，他们的存在受到质疑。这些嗜盐或耐盐粘细菌的迄今探索的成员都被归类为亚目微囊藻。其中很少有化学研究揭示了约11个结构类型属于聚酮化合物，非核糖体肽，其杂交或萜类次级代谢产物。一种最不寻常的结构类型是由来自Enhymmyxa salina的salimabromide代表的。对微囊藻族的四种细菌成员的可用基因组序列进行了计算机分析，揭示了这些细菌的生物合成潜力。
Myxobacteria are famous for their ability to produce most intriguing secondary metabolites. Till recently, only terrestrial myxobacteria were in the focus of research. In this review, however, we discuss marine-derived myxobacteria, which are particularly interesting due to their relatively recent discovery and due to the fact that their very existence was called into question. The to-date-explored members of these halophilic or halotolerant myxobacteria are all grouped into the suborder Nannocystineae. Few of them were chemically investigated revealing around 11 structural types belonging to the polyketide, non-ribosomal peptide, hybrids thereof or terpenoid class of secondary metabolites. A most unusual structural type is represented by salimabromide from Enhygromyxa salina. In silico analyses were carried out on the available genome sequences of four bacterial members of the Nannocystineae, revealing the biosynthetic potential of these bacteria.