Imaging methods in mechanosensing: a historical perspective and visions for the future.
Imaging methods in mechanosensing: a historical perspective and visions for the future.
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DOI：
10.1091/mbc.e20-10-0671
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发表时间：
2021-04-19
影响因子：
3.3
通讯作者：
Dahl KN
中科院分区：
文献类型：
--
作者：
Lavrenyuk K;Conway D;Dahl KN
在过去的三十年里，随着机械生物学成为一个独特的研究领域，研究人员开发了新的成像工具来发现生物力学信号的途径。早期的工作与基板工程和粒子跟踪证明细胞-细胞外基质相互作用的细胞周期的重要性，以及细胞内环境的机械通量。最近，张力传感器方法允许直接测量细胞-细胞和细胞-基质相互作用中的张力。我们回顾性地分析了这些不同的光学技术是如何发展该领域的，并提出了我们对细胞力学统一理论的展望，映射细胞机械传感，以及机械生物学的新生物医学应用。
Over the past three decades, as mechanobiology has become a distinct area of study, researchers have developed novel imaging tools to discover the pathways of biomechanical signaling. Early work with substrate engineering and particle tracking demonstrated the importance of cell–extracellular matrix interactions on the cell cycle as well as the mechanical flux of the intracellular environment. Most recently, tension sensor approaches allowed directly measuring tension in cell–cell and cell–substrate interactions. We retrospectively analyze how these various optical techniques progressed the field and suggest our vision forward for a unified theory of cell mechanics, mapping cellular mechanosensing, and novel biomedical applications for mechanobiology.