Retarded tempo of physiological development in childhood delays the onset of the metabolic syndrome in adulthood.
Retarded tempo of physiological development in childhood delays the onset of the metabolic syndrome in adulthood.
复制标题
儿童期生理发育迟缓会延迟成年期代谢综合征的发病。
DOI：
10.1159/000365872
复制
发表时间：
2014
影响因子：
3.9
通讯作者：
Himes,JohnH
中科院分区：
文献类型：
--
作者：
Sun,ShumeiS;Sima,AdamP;Himes,JohnH
利用Fels纵向研究的系列数据，我们研究了儿童期身高峰值速度（PHV）的早期和晚期达到对以后生活中代谢综合征出现时间的影响。我们的目的是表明，如果早期达到PHV产生更大的风险，慢性疾病的男孩比女孩。因此，我们将研究人群中性别特异性四分位数中达到PHV最慢的男孩和女孩定义为具有缓慢的发育克里思，而那些生长最快达到PHV的男孩和女孩则具有快速的发育克里思。与晚发PHV的男孩相比，早发PHV的男孩发生代谢综合征、血脂异常和空腹血糖受损的风险更高。早期发生PHV的女孩比晚期发生PHV的女孩更容易出现腹部肥胖。
Using serial data from the Fels Longitudinal Study, we investigated the effects of early and late attainment of the peak height velocity (PHV) in childhood on the timing of the appearance of the metabolic syndrome later in life. We aimed to show if early attainment of PHV engenders greater risks for chronic diseases in boys than in girls. Therefore, we defined those boys and girls in sex-specific quartiles of the study population that were slowest to attain PHV as having a slow tempo of development, and those in the growth that most rapidly attained PHV as having a rapid tempo of development. Boys who experienced an early onset of PHV tended to have a higher risk for the metabolic syndrome, dyslipidemia and impaired fasting glucose than those who had late onset of PHV. Girls who had an early onset of PHV tended to develop more abdominal obesity than females who had a late onset of PHV.