ELECTRON-MICROSCOPY OF INFLUENZA HEMAGGLUTININ-MONOCLONAL ANTIBODY COMPLEXES
ELECTRON-MICROSCOPY OF INFLUENZA HEMAGGLUTININ-MONOCLONAL ANTIBODY COMPLEXES
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DOI：
10.1016/0042-6822(83)90499-3
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发表时间：
1983-01-01
期刊：
影响因子：
3.7
通讯作者：
WILEY, DC
中科院分区：
文献类型：
--
作者：
WRIGLEY, NG;BROWN, EB;WILEY, DC
用血凝素-单克隆抗体复合物电镜分析了流感病毒X-31血凝素抗体结合位点的分子位置。我们获得了不同抗体的不同结合位点的证据，并观察到这些位点与抗原位点A、B和E的位置之间的直接对应关系，这些抗原位点是通过确定特定小鼠抗体识别的氨基酸来确定的。
The molecular locations of antibody binding sites on the hemagglutinin of influenza virus X-31 were investigated by EM of hemagglutinin-monoclonal antibody complexes. Evidence was obtained for different sites of binding of different antibodies and direct correspondence was observed between these sites and the locations of antigenic sites A, B, and E, defined by determining the amino acids recognized by the specific mouse antibodies.