Inflammation-type dysbiosis of the oral microbiome associates with the duration of COVID-19 symptoms and long COVID
Inflammation-type dysbiosis of the oral microbiome associates with the duration of COVID-19 symptoms and long COVID
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DOI：
10.1172/jci.insight.152346
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发表时间：
2021-10-20
期刊：
影响因子：
8
通讯作者：
Bucci, Vanni
中科院分区：
文献类型：
--
作者：
Haran, John P.;Bradley, Evan;Bucci, Vanni
在由SARS-CoV-2引起的新冠肺炎大流行中，许多人经历了持久的症状，称为持久的新冠肺炎症状(长冠状病毒病)。慢性COVID被认为与有害炎症引起的免疫失调有关，确切原因尚不清楚。鉴于微生物群在介导炎症中的作用，我们的目标是检查口腔微生物群与长期COVID症状持续时间之间的关系。舌拭子是从出现新冠肺炎症状的患者身上收集的。对确诊的感染进行了跟踪，直到所有症状消失。通过元基因组测序确定细菌组成。我们使用随机森林模型来识别与长期COVID症状相关的微生物区系和临床协变量。在随访的患者中，63%的患者出现持续的症状新冠肺炎，37%的患者继续长期COVID。有长期症状的患者有明显更多的引发炎症的微生物区系，如普雷沃泰拉菌属和韦龙氏菌属，值得注意的是，这是产生内毒素的物种。慢性COVID患者的口腔微生物群与慢性疲劳综合征患者相似。总之，我们的发现表明与口腔微生物群和Long COVID有关，揭示了口腔微生物群功能障碍可能是导致这种引流疾病的原因之一。
In the COVID-19 pandemic, caused by SARS-CoV-2, many individuals experience prolonged symptoms, termed long-lasting COVID-19 symptoms (long COVID). Long COVID is thought to be linked to immune dysregulation due to harmful inflammation, with the exact causes being unknown. Given the role of the microbiome in mediating inflammation, we aimed to examine the relationship between the oral microbiome and the duration of long COVID symptoms. Tongue swabs were collected from patients presenting with COVID-19 symptoms. Confirmed infections were followed until resolution of all symptoms. Bacterial composition was determined by metagenomic sequencing. We used random forest modeling to identify microbiota and clinical covariates that are associated with long COVID symptoms. Of the patients followed, 63% developed ongoing symptomatic COVID-19 and 37% went on to long COVID. Patients with prolonged symptoms had significantly higher abundances of microbiota that induced inflammation, such as members of the genera Prevotella and Veillonella, which, of note, are species that produce LPS. The oral microbiome of patients with long COVID was similar to that of patients with chronic fatigue syndrome. Altogether, our findings suggest an association with the oral microbiome and long COVID, revealing the possibility that dysfunction of the oral microbiome may have contributed to this draining disease.