Early social enrichment shapes social behavior and nerve growth factor and brain-derived neurotrophic factor levels in the adult mouse brain
Early social enrichment shapes social behavior and nerve growth factor and brain-derived neurotrophic factor levels in the adult mouse brain
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DOI：
10.1016/j.biopsych.2006.01.005
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发表时间：
2006-10-01
影响因子：
10.6
通讯作者：
Alleva, Enrico
中科院分区：
文献类型：
--
作者：
Branchi, Igor;D'Andrea, Ivana;Alleva, Enrico
背景资料。早期的经历会在大脑和行为上产生持续的变化。功能。我们调查了在公共巢(CN)中饲养是否对成年的社交/攻击行为和小鼠的神经生长因子(NGF)和脑源性神经营养因子(BDNF)水平产生影响。CN是一种早期社会丰富的形式，具有包括老鼠在内的许多啮齿动物的自然生态位。从出生到断奶(出生后第25天)。结果：与标准实验室条件相比，在CN条件下，小鼠母亲表现出更高的母爱水平。成年后，CN小鼠表现出更高的社会互动倾向，并更迅速地获得主导或从属雄性的行为特征。此外，CN成年小鼠的神经生长因子水平和脑内BDNF水平均较高，而NGF水平受社会地位的影响更大。结论：CN是一个高度刺激的早期社会环境。会在晚年的社会行为中产生差异，这与选定大脑区域(包括海马体和下丘脑)中神经营养素水平的显著变化有关。
Background. Early experiences produce persistent changes in brain and behavioral. function. We investigate whether being reared in a communal nest (CN), a form of early social enrichment that characterizes the natural ecological niche of many rodent species including the mouse, has effects on adult social/aggressive behavior and nerve growth factor (NGF) and brain-derived neurotrophic,factor (BDNF) levels in mice.Methods: The CN consisted of a single nest where three mothers kept their pups together and shared care giving behavior. from birth to weaning (postnatal day 25).Results: Compared to standard laboratory conditions, in CN condition, mouse mothers displayed higher levels of maternal care. At adulthood, CN mice displayed higher propensity to interact socially and achieved more promptly the behavioral profile of either dominant or subordinate male. Furthermore, CN adult mice showed higher NGF levels, which were further affected by social status, and higher BDNF levels in the brain.Conclusions: Our findings indicate that CN, a highly stimulating early social environment. produces differences in social behavior later in life associated with marked changes of neurotrophin levels in selected brain areas, including hippocampus and hypothalamus.