TRUE HAMARTOMA OF THE HYPOTHALAMUS ASSOCIATED WITH PUBERTAS PRAECOX
TRUE HAMARTOMA OF THE HYPOTHALAMUS ASSOCIATED WITH PUBERTAS PRAECOX
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与早熟相关的真正下丘脑错构瘤
DOI：
10.1097/00005072-195110000-00002
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发表时间：
1951
影响因子：
3.2
通讯作者：
R. Richter
中科院分区：
文献类型：
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作者：
R. Richter
神经系统对生物体生命中诸如身体生长和躯体性发育等复杂事件的调节影响仍然引起人们极大的兴趣和好奇。曾经广泛持有的观点认为，早期巨生殖体与松果体疾病特别是与松果体产生的肿瘤特别相关，但这一观点已普遍被怀疑。几乎所有的神经学家和内分泌学家现在都同意，下丘脑，尤其是灰结节，调节生长和性成熟，并且正是该区域的疾病导致了神经源性青春期早发。当然，应当理解，与性腺或肾上腺肿瘤相关的病例被排除在外。这里没有必要回顾导致放弃松果体并采用下丘脑作为人类过早性发育和颅内起源成熟的关键部位的证据。最近对这一论点的阐述可以在 Heuyer、Lhermitte、De Martel 和 Vogt (1)、Horrax 和 Bailey (2) 以及 Weinberger 和 Grant (3) 的论文中找到。 本报告涉及一名 7 岁女童的神经病理学发现，该女童在生命早期就表现出明显的早发巨生殖症。观察结果的价值在于以下事实：存在的下丘脑损伤较小且离散局部，不会损害下丘脑本身，并且不会因对大脑其他部分的继发影响而复杂化。
The regulatory influence of the nervous system upon such elaborate and complex events in the life of the organism as body growth and somatic sexual development remains a source of great interest and wonder. The once widely held opinion that macrogenitosomia praecox was specifically related to disease of the pineal gland, notably to tumors arising from it, has been generally discredited. Almost all neurologists and endocrinologists now agree that the hypothalamus, more especially the tuber cinereum, regulates growth and sexual maturation and that it is disease of this area alone that leads to neurogenic pubertas praecox. It will be understood, of course, that cases associated with gonadal or adrenal tumor are excluded. It is unnecessary to review here the evidence that has led to the abandonment of the pineal gland and the adoption of the hypothalamus as the critical site for premature sexual development and maturation of intracranial origin in man. Recent expositions of the argument may be found in the papers of Heuyer, Lhermitte, De Martel and Vogt (1), Horrax and Bailey (2), and Weinberger and Grant (3).This report concerns the neuropathological findings encountered in a female child, 7 years of age, who presented well marked macrogenitosomia praecox beginning very early in life. The value of the observations lies in the fact that the lesion of the hypothalamus which was present, was small and discretely localized, did not damage the hypothalamus proper, and was not complicated by secondary effects upon other parts of the brain.