Serum concentrations of bisphenol A and its alternatives in elderly population living around e-waste recycling facilities in China: Associations with fasting blood glucose
Serum concentrations of bisphenol A and its alternatives in elderly population living around e-waste recycling facilities in China: Associations with fasting blood glucose
复制标题
中国电子垃圾回收设施周围老年人群血清双酚A及其替代品浓度：与空腹血糖的关系
DOI：
10.1016/j.ecoenv.2018.11.101
复制
发表时间：
2019-03-01
影响因子：
6.8
通讯作者：
Sun, Hongwen
中科院分区：
文献类型：
--
作者：
Song, Shiming;Duan, Yishuang;Sun, Hongwen
本研究对生活在电子垃圾回收设施周围的老年人血清样本中双酚A（BPA）及其6种替代物的浓度进行了定量分析。BPA、双酚AF（BPAF）和双酚F（BPF）在电子废物拆解设施附近居民的血清样本中经常检测到（检出率：> 65%），几何平均（GM）浓度分别为3.2、0.0074和0.062 ng/mL。其他4种双酚在不同采样区域的检出率均低于25%。在电子废物回收和参考区域之间，在BPA的血清浓度中观察到显著差异（Mann Whitney U -检验，p < 0.05），但在BPAF和BPF的血清浓度中没有观察到显著差异。这一发现表明，电子废物拆解活动与人类BPA暴露相关。电子垃圾回收区献血者空腹血糖异常检出率（45%）显著高于参照区（p < 0.05）。我们的研究结果表明，BPA和BPAF暴露可能与生活在电子垃圾场的参与者的异常FBG有关。据我们所知，这项研究是第一次测定血清样本中的BP和评估的健康风险的老年人从BP接触的电子废物拆解区。
In the present study, concentrations of bisphenol A (BPA) and its six alternatives were quantified in serum samples collected from elder population living around an e-waste recycling facilities as well as an reference area in China. BPA, bisphenol AF (BPAF), and bisphenol F (BPF) were frequently detected (detection rates: > 65%) in serum samples collected from residents living near e-waste dismantling facilities, with geometric mean (GM) concentrations of 3.2, 0.0074, and 0.062 ng/mL, respectively. The detection frequencies of other four bisphenols (BPs) in serum samples were lower than 25%, regardless of the sampling areas. Significant difference (Mann Whitney U - test, p < 0.05) was observed in the serum concentration of BPA, but not BPAF and BPF, between the e-waste recycling and reference areas. This finding indicated e-waste dismantling activities are correlated with human BPA exposure. Significant higher (p < 0.05) detection rates of donors who had abnormal fasting blood glucose (FBG) levels were found in e-waste recycling areas (45%) than those found in reference area. Our results suggested BPA and BPAF exposure might associated with abnormal FBG in participants living in e-waste sites. To our knowledge, this study is first determination of BPs in serum samples and assessment of health risk of elderly people from BPs exposure in e-waste dismantling area.