Electroretinographic effects of retinal dragging and retinal folds in eyes with familial exudative vitreoretinopathy.
Electroretinographic effects of retinal dragging and retinal folds in eyes with familial exudative vitreoretinopathy.
复制标题
家族性渗出性玻璃体视网膜病变眼视网膜拖曳和视网膜皱襞的视网膜电图效应
DOI：
10.1038/srep30523
复制
发表时间：
2016-07-26
影响因子：
4.6
通讯作者：
Azuma N
中科院分区：
文献类型：
--
作者：
Yaguchi Y;Katagiri S;Fukushima Y;Yokoi T;Nishina S;Kondo M;Azuma N
应用全场视网膜电图(ERG)对家族性渗出性玻璃体视网膜病变(FEVR)患者的视网膜拖曳(RDrag)和放射状视网膜皱褶(Rfolds)的视网膜功能进行了评价。对9例17眼FEVR患者行Rdragor Rfolds检查的资料进行了回顾性研究。根据视网膜病变的严重程度分为4组：无Rdragor Rfolds组5只眼，合并Rdragor Rfolds组4只眼，伴Rfolds组6只眼，累及所有主要视网膜血管的Rfoldsin组2只眼。视网膜各成分的振幅、明视a波、b波和30 Hz闪光反应的潜伏期随视网膜病变程度的加重而减少或延长(P<； )。第3组和第4组所有眼的明视负反应最严重，几乎检测不到，而第3组的所有眼和第4组的1只眼均可检测到其他ERG成分。这些结果表明，FEVR患者的视网膜功能下降与Rdrag和Rfoldsd的严重程度有关。此外，与其他细胞相比，视网膜神经节细胞的功能受到的影响似乎更严重。
We evaluated the retinal function of retinal dragging (Rdrag) and radial retinal folds (Rfolds) in eyes with familial exudative vitreoretinopathy (FEVR) using full-field electroretinography (ERG). Seventeen eyes of nine patients with FEVR who had Rdragor Rfoldswere retrospectively studied. Eyes were classified into four groups according to the severity of the retinal alterations: Group 1, without Rdragor Rfolds(5 eyes); Group 2, with Rdrag(4 eyes); Group 3, with Rfolds(6 eyes); and Group 4, with Rfoldsin which all major retinal vessels were involved (2 eyes). The amplitudes of all ERG components and the implicit times of the photopic a- and b-waves and 30-Hz flicker responses were decreased or prolonged as the severity of the retinal alterations increased (P< 0.01). The photopic negative response was most severely affected and nearly undetectable in all eyes in Groups 3 and 4, although the other ERG components were detectable in all eyes in Group 3 and one eye in Group 4. These results suggest the decrease of retinal functions was correlated with the degree of severity of Rdragand Rfoldsin eyes with FEVR. In addition, the function of the retinal ganglion cells appears to be more severely affected compared with the others.