Measurement of intravenously administered γ-Fe2O3 particle amount in mice tissues using vibrating sample magnetometer.
Measurement of intravenously administered γ-Fe2O3 particle amount in mice tissues using vibrating sample magnetometer.
复制标题
使用振动样品磁力计测量小鼠组织中静脉注射的 γ-Fe2O3 颗粒量。
DOI：
10.1109/tnb.2014.2337659
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Kita E.
中科院分区：
文献类型：
--
作者：
Kishimoto M;Miyamoto R;Oda T;Ohara Y;Yanagihara H;Ohkohchi N;Kita E.
将30- 50 nm的血小板γ-Fe_2 O_3颗粒经小鼠静脉给药，用振动样品磁强计测量其磁化强度，获得各组织中聚集的颗粒量。在500 Oe的磁场下测量干组织，大大降低了背景噪声，因此抗磁性的影响很小。在肝脏和脾脏中观察到显著的颗粒蓄积。当给予大量γ-Fe_2O_3颗粒时，在肺中观察到相当大的颗粒积聚。肾脏和心脏中无显著颗粒蓄积。
Dispersions of platelet γ-Fe2O3particles 30-50nm in size were intravenously administered to mice and the amount of particles accumulated in each tissue was obtained by magnetization measurement using a vibrating sample magnetometer. Background noise was greatly reduced by measuring dried tissues under a magnetic field of 500 Oe so that the effect of diamagnetism was slight. Remarkable particle accumulation was observed in the liver and spleen. Considerable particle accumulation was observed in the lung when a large quantity of γ-Fe2O3particles was administered. There was no significant particle accumulation in the kidney and heart.