Frailty Prevalence in Younger End-Stage Kidney Disease Patients Undergoing Dialysis and Transplantation
Frailty Prevalence in Younger End-Stage Kidney Disease Patients Undergoing Dialysis and Transplantation
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DOI：
10.1159/000508576
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发表时间：
2020-07-01
影响因子：
4.2
通讯作者：
McAdams-DeMarco, Mara A.
中科院分区：
文献类型：
--
作者：
Chu, Nadia M.;Chen, Xiaomeng;McAdams-DeMarco, Mara A.
背景：虚弱最初以社区老年人为特征，现在越来越多地针对所有年龄段（>18岁）的终末期肾病（ESKD）成年患者进行研究和实施。在年轻人中，虚弱的患病率和表现尚不清楚（18-64岁）;根据患者是否接受血液透析（HD）或肾移植（KT）治疗，可能存在差异。方法：我们利用3个队列：378名成人开始HD（2008-2012），4，304名成人KT候选人（2009-2019）和1，396名KT接受者（2008-2019）。在透析开始后6个月内、KT评估和KT入院时测量虚弱表型。根据年龄估计虚弱及其组成部分的患病率（>= 65 vs. 0.1）。接受者和HD patient.Conclusions：虽然虚弱患病率随年龄增加，年轻患者有很高的负担。照顾这一弱势群体的临床医生应该认识到，年轻患者可能会出现虚弱，并对所有年龄组进行筛查。
Background:Frailty, originally characterized in community-dwelling older adults, is increasingly being studied and implemented for adult patients with end-stage kidney disease (ESKD) of all ages (>18 years). Frailty prevalence and manifestation are unclear in younger adults (18-64 years) with ESKD; differences likely exist based on whether the patients are treated with hemodialysis (HD) or kidney transplantation (KT).Methods:We leveraged 3 cohorts: 378 adults initiating HD (2008-2012), 4,304 adult KT candidates (2009-2019), and 1,396 KT recipients (2008-2019). The frailty phenotype was measured within 6 months of dialysis initiation, at KT evaluation, and KT admission. Prevalence of frailty and its components was estimated by age (>= 65 vs. 0.1). Similar results were observed for recipients and HD patients.Conclusions:Although frailty prevalence increases with age, younger patients have a high burden. Clinicians caring for this vulnerable population should recognize that younger patients may experience frailty and screen all age groups.