Effects of donepezil on cognitive performance after sleep deprivation
Effects of donepezil on cognitive performance after sleep deprivation
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DOI：
10.1002/hup.1248
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发表时间：
2011-12-01
影响因子：
1.7
通讯作者：
Nathan, Pradeep J.
中科院分区：
文献类型：
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作者：
Dodds, Chris M.;Bullmore, Edward T.;Nathan, Pradeep J.
目的确定睡眠剥夺后对认知能力暂时下降敏感的任务，并研究乙酰胆碱酯酶抑制剂多奈哌齐逆转任何睡眠剥夺引起的损害的能力。方法采用双盲平行组设计，30名健康志愿者每天服用5毫克多奈哌齐或安慰剂，持续14-17天，然后在非盲交叉中进行24小时睡眠剥夺或正常睡眠，随后进行一系列认知任务测试，旨在测量记忆和执行功能的不同组成部分。结果：睡眠剥夺选择性地损害了一些记忆任务的表现，同时也损害了这些任务的非记忆功能。其他任务的性能没有受到影响。尽管部分逆转了与睡眠剥夺相关的主观警觉性下降，但用多奈哌齐治疗未能显著扭转任何任务中认知表现的下降。研究结果表明，某些测试，特别是那些测量记忆功能的测试，对睡眠剥夺后的认知损伤具有敏感性。多奈哌齐无法逆转这种表现下降，这表明认知障碍的睡眠剥夺模型可能不适合检测胆碱能增强的促认知作用。版权所有：John Wiley & Sons， Ltd。
Objectives To identify tasks that were sensitive to a temporary decline in cognitive performance after sleep deprivation and to investigate the ability of the acetylcholinesterase inhibitor donepezil to reverse any sleep deprivation-induced impairment.Methods Thirty healthy volunteers were administered either a 5-mg daily dose of donepezil or placebo for 14-17 days, in a double-blind parallel group design, then underwent either 24 h sleep deprivation or a normal night of sleep in non-blinded crossover, and were subsequently tested on a battery of cognitive tasks designed to measure different components of memory and executive function.Results Sleep deprivation selectively impaired performance on several memory tasks whilst also impairing non-memory function on these tasks. Performance on other tasks was spared. Despite partially reversing the decline in subjective alertness associated with sleep deprivation, treatment with donepezil failed to significantly reverse the decline in cognitive performance on any of the tasks.Conclusions The results demonstrate the sensitivity of certain tests, particularly those that measure memory function, to cognitive impairment after sleep deprivation. The inability of donepezil to reverse this performance decline suggests that the sleep deprivation model of cognitive impairment may not be suitable for detecting pro-cognitive effects of cholinergic augmentation. Copyright (C) 2011 John Wiley & Sons, Ltd.