Streptococcus agalactiae Inhibits Candida albicans Hyphal Development and Diminishes Host Vaginal Mucosal TH17 Response.
Streptococcus agalactiae Inhibits Candida albicans Hyphal Development and Diminishes Host Vaginal Mucosal TH17 Response.
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无乳链球菌抑制白色念珠菌菌丝发育并降低宿主阴道粘膜 TH17 反应
DOI：
10.3389/fmicb.2018.00198
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发表时间：
2018
影响因子：
5.2
通讯作者：
Wu WJ
中科院分区：
文献类型：
--
作者：
Yu XY;Fu F;Kong WN;Xuan QK;Wen DH;Chen XQ;He YM;He LH;Guo J;Zhou AP;Xi YH;Ni LJ;Yao YF;Wu WJ
无乳链球菌和白色念珠菌常共同定植于女性生殖道，并在一定条件下诱发粘膜炎症。这两种生物体之间的相互作用在念珠菌阴道炎中的作用尚不清楚。在本研究中，我们发现，与S。agalactiae显著抑制了C.白念珠菌EFG 1-Hwp 1信号通路。白色念珠菌参与了这一过程。在外阴阴道念珠菌病（VVC）小鼠模型中，真菌负荷和促炎细胞因子IL-1β、IL-6和TNF-α的水平在与S.宫颈阴道灌洗液中TH 17 T细胞和IL-17水平显著降低。结果表明，S. agalactiae抑制C.通过下调EFG 1-Hwp 1的表达抑制白念珠菌菌丝生长。S. agalactiae和C.白色念珠菌可能减弱宿主阴道粘膜TH 17免疫，并促进念珠菌在粘膜定植。白色念珠菌
Streptococcus agalactiae and Candida albicans often co-colonize the female genital tract, and under certain conditions induce mucosal inflammation. The role of the interaction between the two organisms in candidal vaginitis is not known. In this study, we found that co-infection with S. agalactiae significantly attenuated the hyphal development of C. albicans, and that EFG1-Hwp1 signal pathway of C. albicans was involved in this process. In a mouse model of vulvovaginal candidiasis (VVC), the fungal burden and the levels of pro-inflammatory cytokines, IL-1β, IL-6 and TNF-α showed a increase on co-infection with S. agalactiae, while the level of TH17 T cells and IL-17 in the cervicovaginal lavage fluid were significantly decreased. Our results indicate that S. agalactiae inhibits C. albicans hyphal development by downregulating the expression of EFG1-Hwp1. The interaction between S. agalactiae and C. albicans may attenuate host vaginal mucosal TH17 immunity and contribute to mucosal colonization by C. albicans.