Interleukin-1α controls allergic sensitization to inhaled house dust mite via the epithelial release of GM-CSF and IL-33.
Interleukin-1α controls allergic sensitization to inhaled house dust mite via the epithelial release of GM-CSF and IL-33.
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DOI：
10.1084/jem.20112691
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发表时间：
2012-07-30
期刊：
影响因子：
--
通讯作者：
Hammad H
中科院分区：
文献类型：
--
作者：
Willart MA;Deswarte K;Pouliot P;Braun H;Beyaert R;Lambrecht BN;Hammad H
IL-1α促进上皮细胞产生一系列细胞因子，最终达到对屋尘螨过敏原的Th2型免疫。屋尘螨(HDM)是世界上最常见的过敏原之一。在这项研究中，我们探讨了IL-1参与HDM与肺上皮细胞(ECs)和树突状细胞(DC)驱动的天然免疫反应之间的相互作用，从而导致哮喘。在抗辐射细胞上缺乏IL-1R的小鼠，而不是造血细胞上，未能产生Th2免疫反应，也没有发生HDM哮喘。在体内和在分离的气液界面培养的支气管内皮细胞中进行的实验表明，TLR4信号诱导IL-1α的释放，然后以自分泌的方式触发DC吸引趋化因子GM-CSF和IL-33的释放。因此，当IL-1CSF、GM-α或IL-33被中和时，体内对HDM的过敏反应被取消。胸腺间质淋巴生成素(TSLP)只有在高剂量过敏原注射时才变得重要。这些发现使IL-1α位于细胞因子级联反应的上游，导致上皮和DC对吸入的HDM变应原的激活。
IL-1α promotes a cascade of cytokine production from epithelial cells culminating in Th2 immunity to house dust mite allergens. House dust mite (HDM) is one of the most common allergens worldwide. In this study, we have addressed the involvement of IL-1 in the interaction between HDM and the innate immune response driven by lung epithelial cells (ECs) and dendritic cells (DCs) that leads to asthma. Mice lacking IL-1R on radioresistant cells, but not hematopoietic cells, failed to mount a Th2 immune response and did not develop asthma to HDM. Experiments performed in vivo and in isolated air–liquid interface cultures of bronchial ECs showed that TLR4 signals induced the release of IL-1α, which then acted in an autocrine manner to trigger the release of DC-attracting chemokines, GM-CSF, and IL-33. Consequently, allergic sensitization to HDM was abolished in vivo when IL-1α, GM-CSF, or IL-33 was neutralized. Thymic stromal lymphopoietin (TSLP) became important only when high doses of allergen were administered. These findings put IL-1α upstream in the cytokine cascade leading to epithelial and DC activation in response to inhaled HDM allergen.
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DOI：
10.1084/jem.20062211
发表时间：
2007-02-19
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Allakhverdi Z;Comeau MR;Jessup HK;Yoon BR;Brewer A;Chartier S;Paquette N;Ziegler SF;Sarfati M;Delespesse G
通讯作者：
Delespesse G
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DOI：
10.4049/jimmunol.1100355
发表时间：
2011-08-01
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Kashyap M;Rochman Y;Spolski R;Samsel L;Leonard WJ
通讯作者：
Leonard WJ
尖端：抑制视黄素X受体对NF-kappab介导的TSLP表达的抑制作用。
影响因子：
4.4
作者：
Lee, Hai-Chon;Headley, Mark B.;Iseki, Masanori;Ikuta, Koichi;Ziegler, Steven F.
通讯作者：
Ziegler, Steven F.
影响因子：
82.9
作者：
Chen, Chun-Jen;Kono, Hajime;Rock, Kenneth L.
通讯作者：
Rock, Kenneth L.
影响因子：
15.9
作者：
Lambrecht, BN;De Veerman, M;Pauwels, RA
通讯作者：
Pauwels, RA