Mechanisms Underlying the Regulation of Innate and Adaptive Immunity by Vitamin D.
Mechanisms Underlying the Regulation of Innate and Adaptive Immunity by Vitamin D.
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DOI：
10.3390/nu7105392
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发表时间：
2015-09-24
期刊：
影响因子：
5.9
通讯作者：
Christakos S
中科院分区：
文献类型：
--
作者：
Wei R;Christakos S
维生素D的非经典作用首次被提出是在30多年前，当时在各种组织和细胞中发现了维生素D的活性形式1，25-二羟基维生素D3(1，25(OH)2D3)的受体，这些组织和细胞与钙稳态的调节无关，包括激活的人类炎症细胞。仍然存在的问题是不同组织和细胞中维生素D受体的存在的生物学意义，以及关于免疫系统，维生素D是否在正常免疫反应和改变免疫介导的疾病中发挥作用。本文综述了维生素D是调节先天免疫和获得性免疫的关键因素的研究结果，并着重介绍了其中涉及的分子机制。此外，还讨论了维生素D作用的生理意义，如在小鼠模型中的活体研究所提示的那样。综上所述，这些发现表明了1，25(OH)2D3作为免疫系统关键成分调节剂的重要性。对相关机制的了解将导致免疫介导性疾病的潜在治疗应用。
Non-classical actions of vitamin D were first suggested over 30 years ago when receptors for the active form of vitamin D, 1,25-dihydroxyvitamin D3 (1,25(OH)2D3), were detected in various tissues and cells that are not associated with the regulation of calcium homeostasis, including activated human inflammatory cells. The question that remained was the biological significance of the presence of vitamin D receptors in the different tissues and cells and, with regard to the immune system, whether or not vitamin D plays a role in the normal immune response and in modifying immune mediated diseases. In this article findings indicating that vitamin D is a key factor regulating both innate and adaptive immunity are reviewed with a focus on the molecular mechanisms involved. In addition, the physiological significance of vitamin D action, as suggested by in vivo studies in mouse models is discussed. Together, the findings indicate the importance of 1,25(OH)2D3 as a regulator of key components of the immune system. An understanding of the mechanisms involved will lead to potential therapeutic applications for the treatment of immune mediated diseases.