Preterm Delivery and Long-term Risk of Hypertension in Women
Preterm Delivery and Long-term Risk of Hypertension in Women
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DOI：
10.1001/jamacardio.2021.4127
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发表时间：
2021-10-13
期刊：
影响因子：
24
通讯作者：
Sundquist, Kristina
中科院分区：
文献类型：
--
作者：
Crump, Casey;Sundquist, Jan;Sundquist, Kristina
IMPORTANCE Preterm delivery has been associated with future cardiometabolic disorders in women. However, the long-term risks of chronic hypertension associated with preterm delivery and whether such risks are attributable to familial confounding are unclear. Such knowledge is needed to improve long-term risk assessment, clinical monitoring, and cardiovascular prevention strategies in women.OBJECTIVE To examine the long-term risks of chronic hypertension associated with preterm delivery in a large population-based cohort of women.DESIGN, SETTING, AND PARTICIPANTS This national cohort study assessed all 2 195 989 women in Sweden with a singleton delivery from January 1, 1973, to December 31, 2015. Data analyses were conducted from March 8, 2021, to August 20, 2021.EXPOSURES Pregnancy duration identified from nationwide birth records.MAIN OUTCOMES AND MEASURES New-onset chronic hypertension identified from primary care, specialty outpatient, and inpatient diagnoses using administrative data. Cox proportional hazards regression was used to compute hazard ratios (HRs) while adjusting for preeclampsia, other hypertensive disorders of pregnancy, and other maternal factors. Cosibling analyses were assessed for potential confounding by shared familial (genetic and/or environmental) factors.RESULTS In 46.1 million person-years of follow-up, 351 189 of 2 195 989 women (16.0%) were diagnosed with hypertension (mean [SD] age, 55.4 [9.9] years). Within 10 years after delivery, the adjusted HR for hypertension associated with preterm delivery (gestational age
