Comparative study of the efficacy of combined cryotherapy and intralesional meglumine antimoniate (Glucantime®) vs. cryotherapy and intralesional meglumine antimoniate (Glucantime®) alone for the treatment of cutaneous leishmaniasis
Comparative study of the efficacy of combined cryotherapy and intralesional meglumine antimoniate (Glucantime®) vs. cryotherapy and intralesional meglumine antimoniate (Glucantime®) alone for the treatment of cutaneous leishmaniasis
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DOI：
10.1111/j.1365-4632.2004.02002.x
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发表时间：
2004-04-01
影响因子：
3.6
通讯作者：
Momeni, A
中科院分区：
文献类型：
--
作者：
Asilian, A;Sadeghinia, A;Momeni, A
背景皮肤利什曼病是由利什曼原虫引起的一种寄生虫病。目的评价冷冻联合病灶内注射锑葡胺(MA)治疗慢性淋巴细胞性白血病的疗效。方法将患者分为3组：第1组100例患者149个病灶采用冷冻治疗；第2组200例230个病灶采用冷冻治疗；第3组100例160个病灶采用病灶内冷冻治疗。结果1组治愈率为90.9%，2组治愈率为57.15%，3组治愈率为55.63%，差异有统计学意义(P<；0.05)。结论冷冻联合MA治疗CL的疗效优于单纯冷冻治疗和单纯MA治疗。
Background Cutaneous leishmaniasis (CL) is a parasitic disease caused by Leishmania species. There is a need for more effective and less time-consuming therapeutic methods for this condition.Aim To evaluate the efficacy of combined cryotherapy and intralesional meglumine antimoniate (MA) (Glucantime(R), Specia, Paris, France) for the treatment of CL.Methods Patients were divided into three groups: Group 1, 100 patients with 149 lesions were treated with cryotherapy plus intralesional MA; Group 2, 200 patients with 230 lesions were treated with cryotherapy; Group 3, 100 patients with 160 lesions were treated with intralesional MA. These groups were followed for 6 months after the end of treatment.Results The results showed complete cure in 90.9% of cases in Group 1, 57.15% of cases in Group 2, and 55.63% of cases in Group 3. The difference between Group 1 and the other groups was statistically significant (P < 0.05).Conclusions Combined cryotherapy and intralesional MA is more effective than either cryotherapy or intralesional MA alone for the treatment of CL.