Proton Therapy in the Management of Pancreatic Cancer.
Proton Therapy in the Management of Pancreatic Cancer.
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放射治疗在胰腺癌的治疗中起着关键的作用，主要是在边缘性可切除肿瘤的新辅助治疗中，以及在不可切除的局部疾病的明确治疗中。胰腺癌的研究大多采用光子放射治疗方式。然而，人们对质子治疗胃肠道肿瘤的应用越来越感兴趣。本文综述了质子治疗在胰腺癌治疗中的应用。放射治疗在胰腺癌的治疗中起着核心作用。虽然质子照射通常被证明是可行的，特别是当计划消融剂量时，仍然是一个挑战，特别是由于肿瘤的运动和接近危险器官，如胃，十二指肠和肠。临床上，根据非随机比较研究，标准剂量的质子放射治疗与光子放射治疗在肿瘤预后和毒性方面没有统计学差异。质子治疗的分步计划和同步化疗组合尚未得到优化，并且是正在进行的试验的主题。
Radiation treatment plays a pivotal a role in the management of pancreatic cancer, mainly in the neoadjuvant setting for borderline resectable tumors and in the definitive setting for unresectable localized disease. Most of the studies on pancreatic cancer use photon-based radiation therapy modalities. However, there is a growing interest in the application of protons therapy for gastrointestinal cancers. This review summarizes the literature on the use of proton therapy in the management of pancreatic cancer. Radiation therapy plays a central role in the treatment of pancreatic cancer. While generally shown to be feasible, proton irradiation, particularly when an ablative dose is planned, remains a challenge, especially due to tumor motion and the proximity to organs at risk, like the stomach, duodenum, and bowel. Clinically, standard doses of proton radiation treatment have not been shown to be statistically different from photon radiation treatment in terms of oncologic outcomes and toxicity rates as per non-randomized comparative studies. Fractionation schedules and concurrent chemotherapy combinations are yet to be optimized for proton therapy and are the subject of ongoing trials.
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影响因子：
1.7
作者：
Fang P;Shiraishi Y;Verma V;Jiang W;Song J;Hobbs BP;Lin SH
通讯作者：
Lin SH
影响因子：
9
作者：
Jolissaint JS;Reyngold M;Bassmann J;Seier KP;Gönen M;Varghese AM;Yu KH;Park W;O'Reilly EM;Balachandran VP;D'Angelica MI;Drebin JA;Kingham TP;Soares KC;Jarnagin WR;Crane CH;Wei AC
通讯作者：
Wei AC
影响因子：
4.1
作者：
De B;Ng SP;Liu AY;Avila S;Tao R;Holliday EB;Brownlee Z;Kaseb A;Lee S;Raghav K;Vauthey JN;Minsky BD;Herman JM;Das P;Smith GL;Taniguchi CM;Krishnan S;Crane CH;Grassberger C;Hong TS;Lin SH;Koong AC;Mohan R;Koay EJ
通讯作者：
Koay EJ
影响因子：
9
作者：
Klinkenbijl, JH;Jeekel, J;Wils, J
通讯作者：
Wils, J
DOI：
10.1016/j.ijrobp.2009.10.061
发表时间：
2011-01-01
影响因子：
7
作者：
Hong, Theodore S.;Ryan, David P.;Fernandez-Del Castillo, Carlos
通讯作者：
Fernandez-Del Castillo, Carlos