Online HIV prophylaxis delivery: Protocol for the ePrEP Kenya pilot study.
Online HIV prophylaxis delivery: Protocol for the ePrEP Kenya pilot study.
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DOI：
10.3389/fpubh.2023.1054559
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发表时间：
2023
影响因子：
5.2
通讯作者：
Ortblad, Katrina F.
中科院分区：
文献类型：
--
作者：
Kiptinness, Catherine;Naik, Paulami;Thuo, Nicholas;Malen, Rachel C.;Dettinger, Julia C.;Pintye, Jillian;Rafferty, Maeve;Jomo, Edwin;Nyamasyo, Nicky;Wood, Tony;Isabelli, Paul;Morris, Sarah;Hattery, David;Stergachis, Andy;Were, Daniel;Sharma, Monisha;Ngure, Kenneth;Mugambi, Melissa Latigo;Ortblad, Katrina F.
肯尼亚的网上药店提供性健康和生殖健康产品（例如，艾滋病毒自我检测、避孕），并可用于扩大艾滋病毒暴露前和暴露后预防（PrEP/PEP）对不经常去卫生设施的人群的覆盖面。到目前为止，证据是有限的，可操作的在线PrEP/PEP交付和类型的人口达到了这种差异化的服务提供模式。ePrEP肯尼亚试点将通过私营在线药店零售商MYDAWA向内罗毕的客户提供每日口服PrEP和PEP，为期18个月。潜在的客户将在MYDAWA的性健康页面上获得有关PrEP/PEP的信息，并进行艾滋病毒风险的自我筛查。年龄≥18岁，被确定为HIV风险，并愿意支付基于血液的HIV自我检测和PrEP/PEP交付的个人将有资格入组。为了继续在线PrEP/PEP启动，符合条件的客户将购买250 KES（约2美元）的基于血液的HIV自我检测[交付给他们选择的设置99 KES（约1美元）]，上传他们的自我检测结果的图像，并参加MYDAWA提供者的远程医疗访问。在远程医疗访问期间，提供者将筛选客户的PrEP/PEP资格，包括临床问题（例如，肾脏疾病），讨论自我测试结果，并完成关于PrEP/PEP使用和安全性的咨询。提供者将把艾滋病毒自我检测呈阳性或报告任何现有医疗状况的客户转介到符合其偏好的医疗机构的适当服务。符合条件的客户将免费获得PrEP（开始时提供30天PrEP;随访时提供90天PrEP）或PEP（28天供应），并以99 KES（约1美元）交付。我们将衡量符合条件的客户中的PrEP和PEP启动，PEP到PrEP的过渡，PrEP的延续和实施结果（例如，可行性、可接受性和成本）。建立途径以增加PrEP和PEP的获得对于帮助遏制艾滋病毒高流行率环境中的新艾滋病毒感染至关重要。这项研究的结果将提供关于实施在线药房PrEP和PEP服务的证据，这些服务可以帮助为肯尼亚和类似环境的指导方针提供信息。
Online pharmacies in Kenya provide sexual and reproductive health products (e.g., HIV self-testing, contraception) and could be leveraged to increase the reach of HIV pre-exposure and post-exposure prophylaxis (PrEP/PEP) to populations who do not frequently attend health facilities. To date, evidence is limited for operationalizing online PrEP/PEP delivery and the type of populations reached with this differential service delivery model. The ePrEP Kenya Pilot will deliver daily oral PrEP and PEP via MYDAWA, a private online pharmacy retailer, to clients in Nairobi for 18 months. Potential clients will obtain information about PrEP/PEP on MYDAWA's sexual wellness page and self-screen for HIV risk. Individuals ≥18 years, identified as at HIV risk, and willing to pay for a blood-based HIV self-test and PrEP/PEP delivery will be eligible for enrollment. To continue with online PrEP/PEP initiation, eligible clients will purchase a blood-based HIV self-test for 250 KES (~USD 2) [delivered to their setting of choice for 99 KES (~USD 1)], upload an image of their self-test result, and attend a telemedicine visit with a MYDAWA provider. During the telemedicine visit, providers will screen clients for PrEP/PEP eligibility, including clinical concerns (e.g., kidney disease), discuss self-test results, and complete counseling on PrEP/PEP use and safety. Providers will refer clients who self-test HIV positive or report any existing medical conditions to the appropriate services at healthcare facilities that meet their preferences. Eligible clients will be prescribed PrEP (30-day PrEP supply at initiation; 90-day PrEP supply at follow-up visits) or PEP (28-day supply) for free and have it delivered for 99 KES (~USD 1). We will measure PrEP and PEP initiation among eligible clients, PEP-to-PrEP transition, PrEP continuation, and implementation outcomes (e.g., feasibility, acceptability, and costs). Establishing pathways to increase PrEP and PEP access is crucial to help curb new HIV infections in settings with high HIV prevalence. The findings from this study will provide evidence on the implementation of online pharmacy PrEP and PEP service delivery that can help inform guidelines in Kenya and similar settings.
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影响因子：
16.1
作者：
Ngure, Kenneth;Ortblad, Katrina F.;Mogere, Peter;Bardon, Ashley R.;Thomas, Katherine K.;Mangale, Dorothy;Kiptinness, Catherine;Gakuo, Stephen;Mbaire, Sarah;Nyokabi, Jacinta;Mugo, Nelly R.;Baeten, Jared M.
通讯作者：
Baeten, Jared M.
DOI：
10.1016/j.bjid.2020.11.002
发表时间：
2021-01
期刊：
The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases
影响因子：
--
作者：
Hoagland B;Torres TS;Bezerra DRB;Benedetti M;Pimenta C;Veloso VG;Grinsztejn B
通讯作者：
Grinsztejn B
影响因子：
6
作者：
Reed JB;Shrestha P;Were D;Chakare T;Mutegi J;Wakhutu B;Musau A;Nonyana NM;Christensen A;Patel R;Rodrigues J;Eakle R;Curran K;Mohan D
通讯作者：
Mohan D
影响因子：
8.1
作者：
Miller R;Wafula F;Onoka CA;Saligram P;Musiega A;Ogira D;Okpani I;Ejughemre U;Murthy S;Garimella S;Sanderson M;Ettelt S;Allen P;Nambiar D;Salam A;Kweyu E;Hanson K;Goodman C
通讯作者：
Goodman C
DOI：
10.1097/qai.0000000000000124
发表时间：
2014-05-01
影响因子：
3.6
作者：
Kimanga, Davies O.;Ogola, Samuel;Kim, Andrea A.
通讯作者：
Kim, Andrea A.