TGF-beta and immune cells: an important regulatory axis in the tumor microenvironment and progression.
TGF-beta and immune cells: an important regulatory axis in the tumor microenvironment and progression.
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DOI：
10.1016/j.it.2010.04.002
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发表时间：
2010-06
影响因子：
16.8
通讯作者：
Moses HL
中科院分区：
文献类型：
--
作者：
Yang L;Pang Y;Moses HL
Transforming growth factor β (TGF-β) plays an important role in tumor initiation and progression, functioning as both a suppressor and a promoter. The mechanisms underlying this dual role of TGF-β remain unclear. TGF-β exerts systemic immune suppression and inhibits host immunosurveillance. Neutralizing TGF-β enhances CD8+ T-cell- and NK-cell-mediated anti-tumor immune responses. It also increases neutrophil-attracting chemokines resulting in recruitment and activation of neutrophils with an antitumor phenotype. In addition to its systemic effects, TGF-β regulates infiltration of inflammatory/immune cells and cancer-associated fibroblasts in the tumor microenvironment causing direct changes in tumor cells. Understanding TGF-β regulation at the interface of tumor and host immunity should provide insights into developing effective TGF-β antagonists and biomarkers for patient selection and efficacy of TGF-β antagonist treatment.
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影响因子：
11.2
作者：
Bierie, Brian;Stover, Daniel G.;Moses, Harold L.
通讯作者：
Moses, Harold L.
影响因子：
20.3
作者：
Biswas, SK;Gangi, L;Sica, A
通讯作者：
Sica, A
DOI：
10.1073/pnas.0408197102
发表时间：
2005-01-11
影响因子：
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作者：
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通讯作者：
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作者：
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影响因子：
64.5
作者：
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通讯作者：
Piccolo, Stefano