PHYSIOLOGICAL CONCENTRATION OF ESTRADIOL INHIBITS POLYMORPHONUCLEAR LEUKOCYTE CHEMOTAXIS VIA A RECEPTOR-MEDIATED SYSTEM
PHYSIOLOGICAL CONCENTRATION OF ESTRADIOL INHIBITS POLYMORPHONUCLEAR LEUKOCYTE CHEMOTAXIS VIA A RECEPTOR-MEDIATED SYSTEM
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DOI：
10.1016/0024-3205(95)00214-q
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发表时间：
1995-05-12
期刊：
影响因子：
6.1
通讯作者：
IGUCHI, A
中科院分区：
文献类型：
--
作者：
ITO, I;HAYASHI, T;IGUCHI, A
雌激素在体内和体外表现出多种作用，包括免疫调节作用。雌激素发挥其抗雌激素作用的机制尚不清楚。我们研究了雌二醇通过多形核白细胞（PMNs）发挥作用的可能机制，这在免疫应答中很重要。17 β-雌二醇，而不是17 α-雌二醇，以剂量依赖的方式显著降低PMNs对FMLP的趋化性（对照组vs雌激素10-（10相似于-6）M，P
Estrogen exhibits a variety of actions, including immuno-modulatory effects, in vivo and in vitro. The mechanism by which estrogen exerts its antiinflammatory effect is not yet understood. We investigated the possible mechanisms of estradiol acting via the polymorphonuclear leukocytes (PMNs), which are important in the immune response. The agent, 17 beta-estradiol, but not 17 alpha-estradiol, significantly reduced PMNs chemotaxis to FMLP in a dose-dependent manner (control vs estrogen 10-(10 similar to-6)M, P