Biological implications of the Weibull and Gompertz models of aging
Biological implications of the Weibull and Gompertz models of aging
复制标题
DOI：
10.1093/gerona/57.2.b69
复制
发表时间：
2002-02-01
影响因子：
5.1
通讯作者：
Scheuerlein, A
中科院分区：
文献类型：
--
作者：
Ricklefs, RE;Scheuerlein, A
冈珀茨函数和威布尔函数意味着人口老龄化的生物学原因不同。描述死亡率随年龄增加而增加的术语分别是乘法和加法，这可能是由于 Gompertz 模型中个体对外在原因的脆弱性增加以及 Weibull 模型中年龄较大时内在原因占主导地位所致。操纵外在死亡率的实验可以区分这些生物模型。为了便于分析实验数据，我们为 Weibull 和 Gompertz 函数定义了一个老化率 (omega) 指数。每个函数都相当好地描述了模拟死亡年龄中与衰老相关的死亡率的增加。然而，与 Weibull omega(W) 相比，Gompertz omega(G) 对初始死亡率的变化敏感，与衰老相关的死亡率无关。野生种群和圈养种群之间的比较似乎支持鸟类的内在原因模型，但对哺乳动物的这两种模型给出了混合的支持。
Gompertz and Weibull functions imply contrasting biological causes of demographic aging. The terms describing increasing mortality with age are multiplicative and additive, respectively, which could result from an increase in the vulnerability of individuals to extrinsic causes in the Gompertz model and the predominance of intrinsic causes at older ages in the Weibull model. Experiments that manipulate extrinsic mortality can distinguish these biological models. To facilitate analyses of experimental data, we defined a single index for the rate of aging (omega) for the Weibull and Gompertz functions. Each function described the increase in aging-related mortality in simulated ages at death reasonably well. However, in contrast to the Weibull omega(W), the Gompertz omega(G) was sensitive to variation in the initial mortality rate independently of aging-related mortality. Comparisons between wild and captive populations appear to support the intrinsic-causes model for birds, but give mixed support for both models in mammals.