Hypothyroxinemia and hypothermia in rats in response to 2,3,7,8-tetrachlorodibenzo-p-dioxin administration.
Hypothyroxinemia and hypothermia in rats in response to 2,3,7,8-tetrachlorodibenzo-p-dioxin administration.
复制标题
给予 2,3,7,8-四氯二苯并-p-二恶英后，大鼠出现低甲状腺素血症和体温过低。
DOI：
10.1016/0041-008x(83)90123-0
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发表时间：
1983
影响因子：
3.8
通讯作者：
Russell,DH
中科院分区：
文献类型：
--
作者：
Potter,CL;Sipes,IG;Russell,DH
研究了2，3，7，8-四氯二苯并-对-二恶英（TCDD）处理对体温、血清和组织中甲状腺激素、葡萄糖、胰高血糖素、胰岛素和生长抑素水平的影响。在TCDD给药（45 μg/kg）后7天内，与成对喂养的对照组和随意喂养的大鼠相比，大鼠表现出甲状腺功能减退症。体温保持在配对喂养和自由喂养的对照组，但在TCDD治疗的大鼠在2天显着下降。在90 μg TCDD/kg给药后2周内，体温低于35°C，第16天记录的最低平均值为34.5°C。对照大鼠的平均体温范围为36.8 - 37.5 ℃。TCDD给药（45 μg/kg）后一周，血清甲状腺素（T4）下降至配对喂养对照组的46%。游离甲状腺素指数的降低表明，测定的甲状腺素降低反映了激素浓度的降低，而不是蛋白结合的改变。TCDD治疗的大鼠发生低甲状腺素血症和体温过低，但它没有发展成对喂养的控制。在给予45 μg TCDD/kg后1周，血清和胰腺胰岛素水平分别降低至自由进食对照组的25%和76%。摄食量减少被确定为负责生长速度下降和低胰岛素血症，但没有考虑低甲状腺素血症，体温过低，低血糖症后的TCDD管理。血清胰高血糖素或胰腺、肝脏或血清生长抑素水平未检测到显著变化。胃窦生长抑素减少与胃干重增加29%一致。TCDD的延迟毒性可能部分是由于这些激素的改变。
The effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) treatment on body temperature and serum and tissue levels of thyroid hormones, glucose, glucagon, insulin, and somatostatin were investigated. Within 7 days following TCDD administration (45 μg/kg), rats exhibited hypothyroidism compared to pair-fed controls and rats fed ad libitum. Body temperature was maintained in the pair-fed and ad libitum-fed controls but was significantly decreased in TCDD-treated rats at 2 days. Within 2 weeks of the administration of 90 μg TCDD/kg, body temperature was below 35°C with the lowest mean value of 34.5°C recorded on Day 16. Mean body temperatures for control rats ranged from 36.8 to 37.5°C. One week after TCDD administration (45 μg/kg), serum thyroxine (T4) declined to 46% of pair-fed controls. The decreased free-thyroxine index indicated that the measured decrease in thyroxine reflected decreased hormone concentrations as opposed to altered protein binding. Hypoglycemia occurred in TCDD-treated rats subsequent to hypothyroxinemia and hypothermia, but it did not develop in the pair-fed controls. At 1 week after administration of 45 μg TCDD/kg, serum and panceratic insulin levels were reduced to 25 and 76% of ad libitum-fed controls, respectively. Hypophagia was determined to be responsible for the decreased growth rate and hypoinsulinemia but did not account for hypothyroxinemia, hypothermia, and hypoglycemia following the administration of TCDD. No significant alterations were detected in serum glucagon or in pancreatic, hepatic, or serum somatostatin levels. Decreased somatostatin in the gastric antrum coincided with a 29% increase in stomach dry weight. The delayed toxicity of TCDD may result, in part, from these hormonal alterations.