Collaboration of fibronectin matrix with other extracellular signals in morphogenesis and differentiation.
Collaboration of fibronectin matrix with other extracellular signals in morphogenesis and differentiation.
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DOI：
10.1016/j.ceb.2016.03.014
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发表时间：
2016-10
影响因子：
7.5
通讯作者：
Schwarzbauer JE
中科院分区：
文献类型：
--
作者：
Vega ME;Schwarzbauer JE
组织形成和细胞分化依赖于正确组装的细胞外基质（ECM）。纤连蛋白是细胞周围ECM的关键成分，在细胞表面整联蛋白受体和ECM的结构组分之间形成必要的连接。最近使用脊椎动物模型、条件基因敲除、组织外植体和细胞培养系统的研究已经确定了依赖于纤连蛋白及其受体α5β1整联蛋白的发育过程。我们描述了纤维连接蛋白基质在心血管系统，体节和前软骨发育，上皮间质转化的要求。有关分子机制的信息显示了纤连蛋白和整合素在组织形态发生和细胞分化过程中的重要性，以及它们与生长因子的合作来介导细胞行为的变化。
Tissue formation and cell differentiation depend on a properly assembled extracellular matrix (ECM). Fibronectin is a key constituent of the pericellular ECM, forming essential connections between cell surface integrin receptors and structural components of the ECM. Recent studies using vertebrate models, conditional gene knockouts, tissue explants, and cell culture systems have identified developmental processes that depend on fibronectin and its receptor α5β1 integrin. We describe requirements for fibronectin matrix in the cardiovascular system, somite and precartilage development, and epithelial-mesenchymal transition. Information about molecular mechanisms shows the importance of fibronectin and integrins during tissue morphogenesis and cell differentiation, as well as their cooperation with growth factors to mediate changes in cell behaviors.