Esophageal motor activity in children with gastro-esophageal reflux disease and esophagitis
Esophageal motor activity in children with gastro-esophageal reflux disease and esophagitis
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DOI：
10.1097/00005176-200501000-00013
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发表时间：
2005-01-01
影响因子：
2.9
通讯作者：
Nurko, S
中科院分区：
文献类型：
--
作者：
Chitkara, DK;Fortunato, C;Nurko, S
目的：探讨小儿胃食管反流病（GERD）患者食管反流时发生的食管体运动收缩。方法：纳入经24小时pH探针联合食管测压试验（MP24）评估胃食管反流的患者。将患者分为以下组：C组：pH探针正常，EGD正常；1组：pH探针异常，EGD正常；2组：pH、EGD异常伴组织学食管炎。分析反流发作时食管运动功能。结果：纳入25例患者。所有患者食管测压正常。pH探头检测结果显示，1、2组胃食管反流明显多于C组（P < 0.01）。在MP24期间，1组和2组患者在ger前、ger中和ger后每分钟的收缩次数明显减少（P < 0.05）。在延长的胃食管反流发作>5分钟期间，孤立性收缩次数和延长性收缩次数（>7秒）差异有统计学意义（P < 0.05）。结论：胃食管反流患儿食管体收缩异常，收缩次数减少。这表明伴有或不伴有食管炎的反流儿童食管体酸清除受损。
Objective: To evaluate esophageal body motor contractions occurring during esophageal reflux in pediatric patients with gastro-esophageal reflux disease (GERD).Methods: Patients referred for the evaluation of GERD who were evaluated with combined 24-hour pH probe and esophageal manometry test (MP24) were included. Patients were separated into the following groups: Group C - normal pH probe and normal EGD; Group 1 - abnormal pH probe and normal EGD; and Group 2 - abnormal pH probe and EGD with histologic esophagitis. Esophageal motor function during reflux episodes was analyzed.Results: Twenty-five patients were included. All had a normal stationary esophageal manometry. Patients in Groups 1 and 2 had significantly more gastroesophageal reflux by pH probe than Group C (P < 0.01). During the MP24, patients in Group 1 and 2 had significantly fewer contractions per minute pre-, during, and post-GER (P < 0.05). There were significant differences in the number of isolated and prolonged contractions (>7 sec) during prolonged GERD episodes >5 minutes (P < 0.05).Conclusion: Children with GERD have a decreased number and abnormal esophageal body contractions with esophageal reflux. This suggests that children with GERD with and without esophagitis have impaired esophageal body acid clearance.