Concurrent acetylation of FoxO1/3a and p53 due to sirtuins inhibition elicit Bim/PUMA mediated mitochondrial dysfunction and apoptosis in berberine-treated HepG2 cells
Concurrent acetylation of FoxO1/3a and p53 due to sirtuins inhibition elicit Bim/PUMA mediated mitochondrial dysfunction and apoptosis in berberine-treated HepG2 cells
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DOI：
10.1016/j.taap.2015.12.006
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发表时间：
2016-01-15
影响因子：
3.8
通讯作者：
Kakkar, Poonam
中科院分区：
文献类型：
--
作者：
Shukla, Shatrunajay;Sharma, Ankita;Kakkar, Poonam
翻译后修饰，即磷酸化和乙酰化是对真核蛋白正确功能的关键要求。当前的研究旨在解码非固定靶靶标的乙酰化/脱乙酰化的影响，即SIRTUINS（NAD（+）依赖性酶具有赖氨酸脱乙酰酶活性）的FOXO1/3A和p53对寄生的人肝脏处理的人肝瘤细胞。 berberine（100 mu M）显着抑制sirtuins（p
Post-translational modifications i.e. phosphorylation and acetylation are pivotal requirements for proper functioning of eukaryotic proteins. The current study aimed to decode the impact of acetylation/deacetylation of non-histone targets i.e. FoxO1/3a and p53 of sirtuins (NAD(+) dependent enzymes with lysine deacetylase activity) in berberine treated human hepatoma cells. Berberine (100 mu M) inhibited sirtuins significantly (P