MICROCIRCULATORY OBSTRUCTION IN FOCAL CEREBRAL ISCHEMIA - ELECTRON-MICROSCOPIC INVESTIGATION IN MONKEYS
MICROCIRCULATORY OBSTRUCTION IN FOCAL CEREBRAL ISCHEMIA - ELECTRON-MICROSCOPIC INVESTIGATION IN MONKEYS
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DOI：
10.1161/01.str.7.1.25
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发表时间：
1976-01-01
期刊：
影响因子：
8.3
通讯作者：
SUNDT, TM
中科院分区：
文献类型：
--
作者：
LITTLE, JR;KERR, FWL;SUNDT, TM
研究了松鼠猴局灶性脑缺血区微血管的精细结构，比较了碳灌注定义的微血管充盈受损和未受损区域的变化。大脑中动脉（MCA）闭塞后3小时微循环阻塞变得明显，部分原因似乎是血管周围胶质细胞肿胀压迫毛细血管和发展为脑水肿。轻微的内皮肿胀是常见的发现。偶尔发现腔内膜结合体，但它们似乎没有产生明显的阻塞。紧密的内皮连接保持完整，无微红细胞增多的迹象。严重的神经元损伤往往先于微血管阻塞的发生，并且比灌注受损区更为广泛。
The fine structure of the microvasculature in areas of focal cerebral ischemia was studied in squirrel monkeys and the changes in areas of impaired and unimpaired microvascular filling, as defined by carbon perfusion, were compared. Microcirculatory obstruction became evident three hours following middle cerebral artery (MCA) occlusion and appeared to be partly the result of compression of capillaries by perivascular glial swelling and developing cerebral edema. Slight endothelial swelling was a common finding. Intraluminal membrane-bound bodies were occasionally identified but they did not appear to be producing significant obstruction. The tight endothelial junctions remained intact and there was no evidence of accelerated micropinocytosis. Severe neuronal injury frequently preceded the development of the microvascular obstruction and was more widespread than the zones of impaired perfusion.