Opiate receptor blockade in man reduces 2-deoxy-D-glucose-induced food intake but not hunger, thirst, and hypothermia.
Opiate receptor blockade in man reduces 2-deoxy-D-glucose-induced food intake but not hunger, thirst, and hypothermia.
复制标题
人类阿片受体阻断会减少 2-脱氧-D-葡萄糖诱导的食物摄入量，但不会减少饥饿、口渴和体温过低。
DOI：
10.1016/0024-3205(82)90539-2
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发表时间：
1982
期刊：
影响因子：
6.1
通讯作者：
Campbell,RG
中科院分区：
文献类型：
--
作者：
Thompson,DA;Welle,SL;Lilavivat,U;Pénicaud,L;Campbell,RG
阿片肽在哺乳动物中枢神经系统中可作为神经调节剂，以保存能量储存和水。为了在人体中检验这一假设，评估了纳洛酮阿片受体阻滞剂对2-脱氧-D-葡萄糖诱导的葡萄糖缺乏应激的饥饿、口渴和体温过低反应的影响。阿片受体阻滞剂减少应激诱导的食物摄入量，但没有减少由葡萄糖缺乏引起的饥饿感的显著增加。纳洛酮输注未改变皮质醇过多、多饮、体温过低和对2-脱氧-D-葡萄糖的产热反应。虽然这些结果并不表明β-内啡肽对应激诱导的饥饿、体温过低和节水的调节起主要作用，但食物摄入的减少可能是由于饱腹感增强，可能与阿片受体阻断期间胃排空延迟有关。
Opioid peptides may act as neuromodulators in the central nervous system to conserve energy stores and water in mammals. To examine this hypothesis in man, the effect of opiate receptor blockade with naloxone on the hunger, thirst, and hypothermic response to 2-deoxy-D-glucose-induced glucoprivic stress was assessed. Opiate receptor blockade decreased stress-induced food intake but did not reduce marked increases in hunger produced by glucoprivation. Naloxone infusions did not change the hypercortisolemic, polydipsic, hypothermic, and thermogenic response to 2-deoxy-D-glucose. While these results do not suggest a major role for a β-endorphin modulation of stress-induced hunger, hypothermia and water conservation, the reduction of food intake could be due to augmented satiety, perhaps associated with retardation of gastric emptying during opiate receptor blockade.