Increased plasma peroxides and serum oxidized low density lipoprotein antibodies in major depression: Markers that further explain the higher incidence of neurodegeneration and coronary artery disease
Increased plasma peroxides and serum oxidized low density lipoprotein antibodies in major depression: Markers that further explain the higher incidence of neurodegeneration and coronary artery disease
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DOI：
10.1016/j.jad.2009.12.014
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发表时间：
2010-09-01
影响因子：
6.6
通讯作者：
Bosmans, Eugene
中科院分区：
文献类型：
--
作者：
Maes, Michael;Mihaylova, Ivanka;Bosmans, Eugene
背景资料：重度抑郁症的特征在于抗氧化状态降低，炎症和氧化和亚硝化（IO&NS）途径以及炎症-神经退行性（I&ND）途径的诱导。本研究探讨了两个标志物的氧化应激抑郁症，即血浆过氧化物和血清氧化低密度脂蛋白（oxLDL）antibodies.Methods：血液采样54例抑郁症患者（平均+/- SD年龄= 43.5 +/- 11.6岁）和37名正常志愿者（43.6 +/- 11.1岁）。通过汉密尔顿抑郁评定量表测量疾病的严重程度。纤维肌痛和慢性疲劳综合征评定量表被用来衡量严重程度的“心身”症状depressment.Results：我们发现显着较高的血浆过氧化物（p = 0.002）和血清oxLDL抗体（p = 0.0002）在抑郁症患者相比，正常对照组。这两个标记之间没有显着的相关性，并且都独立于彼此预测抑郁症。有显着相关性的oxLDL抗体和分数上两个项目的FF规模，即胃肠道症状和headach.Discussion：结果表明，抑郁症是伴随着氧化应激和脂质过氧化反应的增加。这些结果进一步扩展了抑郁症的IO&NS病理生理学。由于过氧化物和oxLDL抗体的增加是冠状动脉疾病（CAD）和神经退行性变的预测因子，我们的研究结果表明，IO和NS通路参与了抑郁症CAD和神经退行性变的发病率增加。(C)2010 Elsevier B. V.保留所有权利。
Background: Major depression is characterized by a decreased antioxidant status, an induction of the inflammatory and oxidative and nitrosative (IO&NS) pathways and inflammatory-neurodegenerative (I&ND) pathways. This study examines two markers of oxidative stress in depression, i.e. plasma peroxides and serum oxidized LDL (oxLDL) antibodies.Methods: Blood was sampled in 54 patients with major depression (mean +/- SD age = 43.5 +/- 11.6 years) and 37 normal volunteers (43.6 +/- 11.1 years). The severity of illness was measured by means of the Hamilton Depression Rating Scale. The Fibromyalgia and Chronic Fatigue Syndrome Rating Scale was used to measure severity of "psychosomatic" symptoms in depression.Results: We found significantly higher plasma peroxides (p = 0.002) and serum oxLDL antibodies (p = 0.0002) in depressed patients as compared to normal controls. There was no significant correlation between both markers and both independently from each other predicted major depression. There were significant correlations between the oxLDL antibodies and the scores on two items of the FF scale, i.e. gastro-intestinal symptoms and headache.Discussion: The results show that major depression is accompanied by increased oxidative stress and lipid peroxidation. These results further extend the IO&NS pathophysiology of major depression. Since increased peroxides and oxLDL antibodies are predictors of coronary artery disease (CAD) and neurodegeneration, our findings suggest that IO&NS pathways are involved in the increased incidence of both CAD and neurodegeneration in depression. (C) 2010 Elsevier B.V. All rights reserved.