Enhancing patient adherence to fecal microbiota transplantation maintains the long-term clinical effects in ulcerative colitis
Enhancing patient adherence to fecal microbiota transplantation maintains the long-term clinical effects in ulcerative colitis
复制标题
提高患者对粪便微生物群移植的依从性可维持溃疡性结肠炎的长期临床效果
DOI：
10.1097/meg.0000000000001725
复制
发表时间：
2020-08-01
影响因子：
2.1
通讯作者：
Zhang, Faming
中科院分区：
文献类型：
--
作者：
Li, Qianqian;Zhang, Ting;Zhang, Faming
Objectives The way to improve the long-term efficacy of fecal microbiota transplantation (FMT) in ulcerative colitis (UC) remains unclear. This study mainly dedicated to the UC patients' satisfaction with FMT and the importance of patients' adherence to repeated FMT for long-term clinical outcomes. Methods Patients with UC who underwent FMT at our center from November 2012 to September 2018 were included. We assessed patient satisfaction with efficacy, safety, and reliability of FMT, as well as adherence to the repeated FMT. Results One hundred and seventy-six patients were included in the analysis. The median follow-up duration of the study was 25.5 (interquartile range 13.0-46.5) months. The clinical response rate at 1 week, 1 month, 3 months, and 6 months after FMT was 48.9%, 69.3%, 49.4%, and 32.7%, respectively. 3.4% (6/176) of patients underwent colectomy after FMT during our long-term follow-up. Partial Mayo score at 1-month post-FMT (P< 0.001) was an independent factor of patients' satisfaction. The laboratory preparation process was related to the incidence of adverse events (P< 0.05). 23.8% (29/122) of patients with a good adherence followed our recommendation to undergo the second course of FMT and achieved a longer clinical response compared with the patients with poor adherence (P< 0.001). Conclusion Patients' good adherence to repeated FMT is important to maintain long-term clinical benefits achieved from FMT in UC. Registration number: NCT01790061.
