EDTA solutions for the dissolution of calcium bilirubinate stones.
EDTA solutions for the dissolution of calcium bilirubinate stones.
复制标题
EDTA 溶液用于溶解胆红素钙结石。
作者：
U. Leuschner;H. Baumgärtel;M. Leuschner;H. Frenk;X. Klicic
研究了添加5.49%芥子酸钙粉末后不同EDTA溶液对钙离子的螯合作用。钙螯合似乎是分解色素结石的一个重要步骤。我们发现，钙螯合是pH依赖性的，该系统必须缓冲，以防止pH值的变化，在溶解过程中。当碱性（pH 9.4）缓冲的1% EDTA溶液与胆汁以70：30的比例混合时，与不含胆汁的研究相比，钙的溶出度将降低至60%。此外，我们可以证明，EDTA溶液不仅可以溶解胆红素钙粉末，还可以溶解结构均匀的牛色素结石和大部分组成不均匀的人结石。
The calcium chelating of different EDTA solutions was investigated after addition of 5.49% calcium bilirubinate powder. Calcium chelating seems to be an essential step in disaggregation of pigment stones. We found that Ca chelating is pH dependent and that the system must be buffered in order to prevent pH shifting during the dissolution process. When an alkaline (pH 9.4), buffered 1% EDTA solution is mixed with bile in a ratio of 70:30, dissolution of Ca will decrease to 60% as compared to investigations without bile. Furthermore, we could demonstrate that the EDTA solution would not only dissolve Ca bilirubinate powder, but complete bovine pigment stones of homogeneous structure and mostly inhomogenously composed stones of man as well.