FREE CHOLINE CONCENTRATION AND CEPHALIN-N-METHYLTRANSFERASE ACTIVITY IN MATERNAL AND FETAL LIVER AND PLACENTA OF PREGNANT RATS
FREE CHOLINE CONCENTRATION AND CEPHALIN-N-METHYLTRANSFERASE ACTIVITY IN MATERNAL AND FETAL LIVER AND PLACENTA OF PREGNANT RATS
复制标题
DOI：
10.1111/j.1440-1681.1978.tb00721.x
复制
发表时间：
1978-01-01
影响因子：
2.9
通讯作者：
SIM, MK
中科院分区：
文献类型：
--
作者：
GWEE, MCE;SIM, MK
1.本文测定了孕晚期母鼠、胎鼠肝脏和胎盘游离胆碱浓度和脑磷脂-N-甲基转移酶活性。2.肝脏的胆碱浓度从成年非妊娠大鼠的平均130 nmol/g下降到妊娠晚期的38 nmol/g。3.胎肝和胎盘的胆碱浓度平均值分别为135和442 nmol/g。4.有一个显着的24%增加脑磷脂-N-甲基转移酶的活性在怀孕期间的肝脏。胎儿肝脏中的酶活性是母体肝脏的7%，胎盘中检测不到活性。5.结果表明，在怀孕期间，母体肝脏向胎盘和胎儿器官（如肝脏）提供胆碱，并且对母体肝脏胆碱的需求远远超过可用的供应。
1. The concentration of free choline and cephalin-N-methyltransferase activity of the maternal and foetal liver and placenta of rats in late pregnancy were determined. 2. The choline concentration of the liver fell from a mean of 130 nmol/g in adult non-pregnant rats to 38 nmol/g in late pregnancy. 3. The choline concentrations of the foetal liver and placenta had mean values of 135 and 442 nmol/g, respectively. 4. There was a significant 24% increase in the cephalin-N-methyltransferase activity of the liver during pregnancy. The enzyme activity in the foetal liver was 7% that of the maternal liver, and activity was undetectable in the placenta. 5. The results suggest that, during pregnancy, the maternal liver supplies choline to the placenta and foetal organs, like the liver, and that the demand for maternal liver choline far exceeds the supply available.