Arsenic immunotoxicity: a review.
Arsenic immunotoxicity: a review.
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DOI：
10.1186/1476-069x-12-73
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发表时间：
2013-09-02
期刊：
影响因子：
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通讯作者：
Smith MT
中科院分区：
文献类型：
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作者：
Dangleben NL;Skibola CF;Smith MT
砷暴露(As)是一个全球性的公共卫生问题，因为它与各种癌症和许多其他病理影响有关，全世界有数百万人经常接触As。越来越多的证据表明，AS可能会对免疫系统产生不利影响，但其对免疫功能的具体影响却知之甚少。因此，我们进行了与AS暴露相关的非癌症免疫相关效应的文献检索，并总结了已知的AS在人类、动物和体外模型中的免疫毒理学效应。总体而言，数据显示，长期暴露在砷中可能会损害重要的免疫反应，从而可能导致感染和慢性病(包括各种癌症)风险增加。虽然动物和体外模型提供了一些关于在人类群体中观察到的砷相关免疫毒性的潜在机制的见解，但需要进一步的研究，特别是在人类中，以更好地了解AS暴露与疾病发展的关系。
Exposure to arsenic (As) is a global public health problem because of its association with various cancers and numerous other pathological effects, and millions of people worldwide are exposed to As on a regular basis. Increasing lines of evidence indicate that As may adversely affect the immune system, but its specific effects on immune function are poorly understood. Therefore, we conducted a literature search of non-cancer immune-related effects associated with As exposure and summarized the known immunotoxicological effects of As in humans, animals and in vitro models. Overall, the data show that chronic exposure to As has the potential to impair vital immune responses which could lead to increased risk of infections and chronic diseases, including various cancers. Although animal and in vitro models provide some insight into potential mechanisms of the As-related immunotoxicity observed in human populations, further investigation, particularly in humans, is needed to better understand the relationship between As exposure and the development of disease.