Loss of phosphatase and tensin homolog expression correlates with clinicopathological features of non-small cell lung cancer patients and its impact on survival: A systematic review and meta-analysis.
Loss of phosphatase and tensin homolog expression correlates with clinicopathological features of non-small cell lung cancer patients and its impact on survival: A systematic review and meta-analysis.
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磷酸酶和张力蛋白同源物表达的丧失与非小细胞肺癌患者的临床病理特征及其对生存的影响相关：系统评价和荟萃分析
DOI：
10.1111/1759-7714.12425
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发表时间：
2017-05
期刊：
影响因子：
2.9
通讯作者：
Liu L
中科院分区：
文献类型：
--
作者：
Zhao Y;Zheng R;Li J;Lin F;Liu L
磷酸酶和张力蛋白同源物（PTEN）被认为是一种肿瘤抑制基因，可作为人类癌症的预后生物标志物。纳入了截至2016年10月来自MEDLINE、Embase、CENTRAL和中国生物医学文献数据库的所有合格研究。两名评价者根据纳入和排除标准独立筛选文献，提取数据，评估纳入研究的方法学质量，并进行Meta分析。共纳入了来自19项研究的2486例患者。PTEN表达与性别、吸烟史、组织学（腺癌[ADC]与鳞状细胞癌）、肿瘤淋巴结转移分期（I-II与III-IV）、N状态（N 0与N1-N3）和远处转移（M0与M1）显著相关。PTEN表达缺失与总生存率降低相关，但与无病生存率无显著相关性。亚组分析显示，在亚洲和ADC患者中，PTEN阴性表达与较差的预后相关，但在西方或鳞状细胞癌患者中无关。PTEN的缺失可能对非小细胞肺癌患者的总生存率起不利的预后作用，尤其是亚洲或ADC患者。
Phosphatase and tensin homolog (PTEN), regarded as a tumor suppressor gene, may act as a prognostic biomarker in human cancers. All eligible studies from MEDLINE, Embase, CENTRAL, and the Chinese BioMedical Literature Database to October 2016 were incorporated. Two reviewers independently screened the literature according to inclusion and exclusion criteria, extracted the data, assessed the methodological quality of the included studies, and conducted meta‐analysis. A total of 2486 patients from 19 studies were included. PTEN expression was significantly correlated with gender, smoking history, histology (adenocarcinoma [ADC] vs. squamous cell carcinoma), tumor node metastasis stage (I–II vs. III–IV), N status (N0 vs. N1–N3), and distant metastasis (M0 vs. M1). Loss of PTEN expression was associated with poorer overall survival, but had no significant association with disease‐free survival. Subgroup analysis showed that negative PTEN expression was associated with a poorer outcome in Asian and ADC patients, but not in Western or squamous cell carcinoma patients. Loss of PTEN might play an unfavorable prognostic role for overall survival of non‐small cell lung cancer patients, especially Asian or ADC patients.