NKR-P1, A SIGNAL TRANSDUCTION MOLECULE ON NATURAL-KILLER-CELLS
NKR-P1, A SIGNAL TRANSDUCTION MOLECULE ON NATURAL-KILLER-CELLS
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DOI：
10.1126/science.2399464
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发表时间：
1990-09-14
期刊：
影响因子：
56.9
通讯作者：
TRUCCO, M
中科院分区：
文献类型：
--
作者：
GIORDA, R;RUDERT, WA;TRUCCO, M
自然杀伤（NK）细胞是一个大颗粒淋巴细胞的亚群，其特征是密集染色的嗜天青颗粒。NK细胞能够再活化和溶解各种病毒感染或肿瘤靶细胞，而无需先前的致敏或主要组织相容性复合体限制。一个60 kD的二硫键连接的二聚体，在NK细胞上高度表达，被发现能够介导跨膜信号。克隆了编码该信号转导分子的基因，并测定了其核苷酸序列。所编码的蛋白质与许多具有受体特征的凝集素相关膜蛋白具有显着的同源性。这种蛋白质可以作为能够选择性地触发NK细胞活性的受体起作用。
Natural killer (NK) cells are a subpopulation of large granular lymphocytes characterized by densely staining azurophilic granules. NK cells are able to recongize and lyse various virally infected or neoplastic target cells without previous sensitization or major histocompatibility complex restriction. A 60-kDdisulfide-linked dimer, highly expressed on NK cells, was found capable of mediating transmembrane signaling. The gene encoding this signal transduction molecule was cloned and its nucleotide sequence determined. The encoded protein showed significant homology with a number of lectin-related membrane proteins that share receptor characteristics. This protein may function as a receptor able to selectively trigger NK cell activity.