Infant mortality and congenital anomalies from 1950 to 1994: an international perspective
Infant mortality and congenital anomalies from 1950 to 1994: an international perspective
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DOI：
10.1136/jech.54.9.660
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发表时间：
2000-09-01
影响因子：
6.3
通讯作者：
Mastroiacovo, P
中科院分区：
文献类型：
--
作者：
Rosano, A;Botto, LD;Mastroiacovo, P
研究目标-提供一个关于1950-1994年先天性畸形对婴儿死亡率影响的国际视角。设计-以人口为基础的研究，以向世界卫生组织报告的生命统计数据为基础。背景-来自欧洲、中东、美洲、亚洲和南太平洋的36个国家。结果--从1950年到1994年，婴儿死亡率平均下降了68.8%。在所研究的国家中，可归因于先天畸形的婴儿死亡率下降了33.4%，尽管最近在中美洲和拉丁美洲以及东欧的一些国家，这一数字有所上升。先天性异常导致的婴儿死亡中，心脏和中枢神经系统异常占48.9%。1990-1994年期间，在所研究的国家中，可归因于先天畸形的婴儿死亡率与人均国内生产总值呈负相关。与此同时，可归因于先天畸形的婴儿死亡比例与人均国内生产总值直接相关。结论--在发达国家和发展中国家，先天畸形在婴儿死亡中所占的比例都越来越高。可归因于先天畸形的婴儿死亡率在较贫穷国家较高，尽管在婴儿死亡中所占比例在较富裕国家较高。脊柱裂等疾病的发生可以通过预防措施减少，但仍导致许多婴儿死亡。应对一些国家因先天畸形导致的婴儿死亡率明显上升的情况进行调查，以确认这一发现，找出原因，并提供预防机会。
Study objective-To provide an international perspective on the impact of congenital anomalies on infant mortality from 1950 to 1994.Design-Population-based study based on data obtained from vital statistics reported to the World Health Organisation. Settings-36 countries from Europe, the Middle East, the Americas, Asia, and the South Pacific.Results-On average, infant mortality declined 68.8 per cent from 1950 to 1994. In the countries studied, infant mortality attributable to congenital anomalies decreased by 33.4 per cent, although it recently increased in some countries in Central and Latin America and in Eastern Europe. Anomalies of the heart and of the central nervous system accounted for 48.9 per cent of infant deaths attributable to congenital anomalies. During 1990-1994, infant mortality attributable to congenital anomalies was inversely correlated to the per capita gross domestic product in the countries studied. At the same time, the proportion of infant deaths attributable to congenital malformations was directly correlated with the per capita gross domestic product.Conclusions-Congenital malformations account for an increasing proportion of infant deaths in both developed and developing countries. Infant mortality attributable to congenital anomalies is higher in poorer countries although as a proportion of infant deaths it is greater in wealthier countries. Conditions such as spina bifida, whose occurrence can be reduced through preventive strategies, still cause many infant deaths. The apparent increase of infant mortality because of congenital anomalies in some countries should be investigated to confirm the finding, find the causes, and provide prevention opportunities.