Mutagenicity of chromium picolinate and its components in Salmonella typhimurium and L5178Y mouse lymphoma cells.
Mutagenicity of chromium picolinate and its components in Salmonella typhimurium and L5178Y mouse lymphoma cells.
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DOI：
10.1016/j.fct.2005.05.003
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发表时间：
2005-11
期刊：
影响因子：
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通讯作者：
P. Whittaker;R. San;J. Clarke;H. Seifried;V. Dunkel
中科院分区：
文献类型：
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作者：
P. Whittaker;R. San;J. Clarke;H. Seifried;V. Dunkel
吡啶甲酸铬是美国最常用的铬膳食补充剂之一，它已被销售给消费者用于减肥，增加肌肉质量和降低血清胆固醇。吡啶甲酸铬是一种合成化合物，它提供了一种比膳食铬更好吸收的生物可利用形式的铬（III）。然而，有几份报告指出，它可能会产生不利影响。为了研究观察到的细胞毒性和致突变性的机制，在鼠伤寒沙门氏菌和L5178Y小鼠淋巴瘤细胞中评价了吡啶甲酸铬及其组分化合物氯化铬（III）和吡啶甲酸。吡啶甲酸铬和氯化铬均未引起S.鼠伤寒。然而，在L5178Y小鼠淋巴瘤突变试验中，在不添加和添加S9的情况下，吡啶甲酸铬诱导了致突变反应。
Chromium picolinate is one of the most commonly used chromium dietary supplements available in the United States, and it has been marketed to consumers for use in weight loss, increasing muscle mass, and lowering serum cholesterol. Chromium picolinate is a synthetic compound that provides a bioavailable form of Cr(III) that is absorbed better than dietary chromium. However, there are several reports that it can have adverse effects. In order to study the mechanism of observed cellular toxicity and mutagenicity, chromium picolinate and its component compounds, chromium (III) chloride and picolinic acid, were evaluated in Salmonella typhimurium and L5178Y mouse lymphoma cells. Neither chromium picolinate nor chromium chloride induced a mutagenic response in S. typhimurium. However, in the L5178Y mouse lymphoma mutation assay, chromium picolinate induced mutagenic responses without and with the addition of S9.