Maternal risk factors for paediatric inguinal hernia.
Maternal risk factors for paediatric inguinal hernia.
复制标题
小儿腹股沟疝的母亲危险因素。
DOI：
10.1093/bjs/znab337
复制
发表时间：
2021
影响因子：
9.6
通讯作者：
N. Piché
中科院分区：
文献类型：
--
作者：
N. Auger;Francesca del Giorgio;Annie Le;M. Bilodeau;N. Piché
背景
小儿腹股沟疝的危险因素知之甚少。这项纵向队列研究评估了母亲有腹股沟疝或结缔组织疾病病史的儿童在13岁之前患腹股沟疝的风险是否更高。
方法
该研究包括2006-2019年在加拿大魁北克出生至13岁之间随访的儿童。母亲患有腹股沟疝或结缔组织疾病的新生儿随时间进行随访，以确定未来腹股沟疝的住院情况。根据患者特征调整的考克斯比例风险回归用于估计母亲疝或结缔组织疾病与未来儿童疝之间关联的风险比（HR）和95%置信区间。分别对女孩和男孩的联想进行了研究。
结果
该研究包括786322名儿童，随访6186448人年。有6861名儿童腹股沟疝，对应的发病率为11.1/10000人年。母亲有腹股沟疝病史的儿童有2.92（95% c.i. 2.39患腹股沟疝的风险是母亲无此病史的儿童的3.58倍。母亲有结缔组织疾病病史的儿童的风险为1.30（1.00至1.68）倍。母亲疝与女孩腹股沟疝的风险密切相关（HR 5.34，3.82至7.47），而母亲结缔组织疾病与男孩腹股沟疝相关（HR 1.35，1.02至1.79）。
结论
小儿腹股沟疝可能与母亲腹股沟疝和结缔组织疾病有关，但这种关系的根本原因需要进一步调查。
BACKGROUND
Risk factors for paediatric inguinal hernia are poorly understood. This longitudinal cohort study assessed whether children with a maternal history of inguinal hernia or connective tissue disorders have a higher risk of developing inguinal hernias before 13 years of age.
METHODS
The study included children followed up between birth and 13 years of age in Quebec, Canada, 2006-2019. Newborns whose mothers had inguinal hernias or connective tissue disorders were followed over time to identify future hospital admissions for inguinal hernia. Cox proportional hazards regression adjusted for patient characteristics was used to estimate hazard ratios (HRs) and 95 per cent confidence intervals for the association between maternal hernia or connective tissue disorders and future childhood hernias. Associations in girls and boys were examined separately.
RESULTS
The study included 786 322 children with 6 186 448 person-years of follow-up. There were 6861 children with inguinal hernias, corresponding to an incidence of 11.1 per 10 000 person-years. Children with a maternal history of inguinal hernia had 2.92 (95 per cent c.i. 2.39 to 3.58) times the risk of having inguinal hernias relative to children whose mothers had no such history. Children with a maternal history of connective tissue disorders had 1.30 (1.00 to 1.68) times the risk. Maternal hernias were strongly associated with risk of inguinal hernias in girls (HR 5.34, 3.82 to 7.47), whereas maternal connective tissue disorders were associated with inguinal hernias in boys (HR 1.35, 1.02 to 1.79).
CONCLUSION
Paediatric inguinal hernias may be associated with maternal inguinal hernias and connective tissue disorders, but the underlying reason for this relationship requires further investigation.