Aging and animal models of systemic insult: trauma, burn, and sepsis.
Aging and animal models of systemic insult: trauma, burn, and sepsis.
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DOI：
10.1097/shk.0b013e318180f508
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发表时间：
2009-01
期刊：
影响因子：
--
通讯作者：
Kovacs EJ
中科院分区：
文献类型：
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作者：
Nomellini V;Gomez CR;Gamelli RL;Kovacs EJ
在急性护理环境中，人们普遍认为老年患者的发病率和死亡率高于年轻健康患者。然而，其原因在很大程度上是未知的。虽然动物模型有助于改善年轻患者的治疗策略，但很少有研究试图了解老年人全身损伤（如创伤，烧伤和败血症）的机制。这篇综述旨在强调使用动物研究老年人这些损伤的发病机制的相关性，尽管信息不足，总结目前在这一领域所知的。
In the acute-care setting, it is widely accepted that elderly patients have increased morbidity and mortality compared with young healthy patients. The reasons for this, however, are largely unknown. Although animal modeling has helped improve treatment strategies for young patients, there are a scarce number of studies attempting to understand the mechanisms of systemic insults such as trauma, burn, and sepsis in aged individuals. This review aims to highlight the relevance of using animals to study the pathogenesis of these insults in the aged and, despite the deficiency of information, to summarize what is currently known in this field.