Day of injury CT and late MRI findings: Cognitive outcome in a paediatric sample with complicated mild traumatic brain injury.
Day of injury CT and late MRI findings: Cognitive outcome in a paediatric sample with complicated mild traumatic brain injury.
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DOI：
10.3109/02699052.2015.1011234
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发表时间：
2015
期刊：
影响因子：
1.9
通讯作者：
Yeates KO
中科院分区：
文献类型：
--
作者：
Bigler ED;Jantz PB;Farrer TJ;Abildskov TJ;Dennis M;Gerhardt CA;Rubin KH;Stancin T;Taylor HG;Vannatta K;Yeates KO
复杂性轻度创伤性脑损伤（mTBI）或cmTBI是基于损伤当天计算机断层扫描（CT）扫描可见可识别的脑病理学的存在。在一个儿科样本中，DOI CT与晚期MRI结果和神经心理学结果的关系进行了研究。在儿科cmTBI患者和骨科损伤（OI）儿童样本中获得MRI（> 12个月）。将具有阳性成像结果（MRI+）的儿童与没有（MRI-）或具有OI样本的儿童进行定量比较。还比较了WASI子测试和WISC-IV处理速度指数（PSI）的神经认知结果，沿着儿童日常注意力测试（TEA-Ch）和父母评定的行为功能测量（ABAS-II）。尽管MRI+组与MRI-组相比有更多的DOI CT结果，但没有发现定量差异。WASI词汇和矩阵推理得分显著较低，但PSI，TEA-Ch或ABAS-II得分不显著。MRI+和MRI-组在这些指标上没有差异。MRI确定的局灶性病理学发生的异质性与cmTBI中脑结构定量分析的均匀变化无关。DOI CT异常数量的增加与神经心理学表现降低相关。
Complicated mild traumatic brain injury (mTBI) or cmTBI is based on the presence of visibly identifiable brain pathology on the day-of-injury computed tomography (CT) scan. In a pediatric sample the relation of DOI CT to late MRI findings and neuropsychological outcome was examined. MRI (> 12 months) was obtained in pediatric cmTBI patients and a sample of orthopedically injured (OI) children. Those children with positive imaging findings (MRI+) were quantitatively compared to those without (MRI-) or with the OI sample. Groups were also compared in neurocognitive outcome from WASI subtests and the WISC-IV Processing Speed Index (PSI), along with the Test of Everyday Attention for Children (TEA-Ch) and a parent-rated behavioral functioning measure (ABAS-II). Despite the MRI+ group having significantly more DOI CT findings than the MRI-group, no quantitative differences were found. WASI Vocabulary and Matrix Reasoning scores were significantly lower, but not PSI, TEA-Ch or ABAS-II scores. MRI+ and MRI-groups did not differ on these measures. Heterogeneity in the occurrence of MRI-identified focal pathology was not associated with uniform changes in quantitative analyses of brain structure in cmTBI. Increased number of DOI CT abnormalities was associated with lowered neuropsychological performance.