Uterine carcinosarcomas (malignant mixed Mullerian tumors) are metaplastic carcinomas
Uterine carcinosarcomas (malignant mixed Mullerian tumors) are metaplastic carcinomas
复制标题
DOI：
10.1046/j.1525-1438.2002.01151.x
复制
发表时间：
2002-11-01
影响因子：
4.8
通讯作者：
McCluggage, WG
中科院分区：
文献类型：
--
作者：
McCluggage, WG
子宫癌肉瘤（恶性苗勒管混合瘤）传统上被认为是子宫肉瘤的一个亚型。辅助肿瘤学治疗通常与针对高级别子宫肉瘤（如平滑肌肉瘤和未分化子宫肉瘤）的治疗相似。然而，现在有令人信服的证据表明，大多数子宫癌是单克隆肿瘤，实际上是化生性癌。虽然具有侵袭性，但子宫癌肉瘤的行为更类似于高级别子宫内膜样腺癌和侵袭性子宫癌的形态学亚型。肉瘤成分来源于致癌成分，致癌成分是肉瘤形成的驱动力。尽管癌肉瘤的名称可能会保留，但辅助治疗可能应该类似于针对侵袭性高级别子宫内膜癌的治疗。应进行前瞻性研究，以确定这些辅助治疗是否比传统的肉瘤为基础的治疗更有效的治疗这些侵袭性肿瘤。
Uterine carcinosarcomas (malignant mixed Mullerian tumors) have been traditionally regarded as a subtype of uterine sarcoma. Adjuvant oncological treatments have often been similar to those directed against high-grade uterine sarcomas such as leiomyosarcoma and undifferentiated uterine sarcoma. However, there is now convincing evidence that most uterine carcinosarcomas are monoclonal neoplasms and are in reality metaplastic carcinomas. Although aggressive, the behavior of uterine carcinosarcoma is more akin to that of high-grade endometrioid type endometrial adenocarcinoma and aggressive morphological subtypes of uterine carcinoma. The sarcomatous component is derived from the carcinomatous element which is the driving force. Although the designation carcinosarcoma is likely to remain, adjuvant treatments should probably be similar to those directed against aggressive high grade endometrial carcinomas. Prospective studies should be performed to ascertain whether such adjuvant therapies are more effective than traditional sarcoma based therapies in the treatment of these aggressive neoplasms.