ABERRANT REARRANGEMENTS CONTRIBUTE SIGNIFICANTLY TO THE ALLELIC EXCLUSION OF IMMUNOGLOBULIN GENE-EXPRESSION
ABERRANT REARRANGEMENTS CONTRIBUTE SIGNIFICANTLY TO THE ALLELIC EXCLUSION OF IMMUNOGLOBULIN GENE-EXPRESSION
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DOI：
10.1038/290372a0
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发表时间：
1981-01-01
期刊：
影响因子：
64.8
通讯作者：
WEIGERT, M
中科院分区：
文献类型：
--
作者：
COLECLOUGH, C;PERRY, RP;WEIGERT, M
对小鼠脾B细胞、脾源性杂交瘤和浆细胞瘤中轻链和重链IG基因的组织的研究表明，异常重排在正常B细胞发育过程中是常见的。支持IG基因表达的等位基因排斥的概率模型。
A study of the organization of light- and heavy-chain Ig genes in mouse splenic B cells, spleen-derived hybridomas and plasmacytomas has demonstrated that aberrant rearrangements are common during normal B-cell development. A probabilistic model for allelic exclusion of Ig gene expression is supported.