Structural effects of an innovative surgical technique to repair heart valve defects
Structural effects of an innovative surgical technique to repair heart valve defects
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DOI：
10.1016/j.jbiomech.2004.10.005
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发表时间：
2005-12-01
影响因子：
2.4
通讯作者：
Schreiber, M
中科院分区：
文献类型：
--
作者：
Dal Pan, F;Donzella, G;Schreiber, M
研究了“边缘对边缘”技术对人类二尖瓣的结构和功能影响，特别注意舒张期。先进的有限元模型的阀门已经开发，使用超弹性材料schematization，合适的几何形状和约束条件，以及有效的流体动力学分析。在此模型上应用边到边缝合，模拟了舒张期。该计算结果表明，手术增加了跨瓣压和瓣叶中的最大应力，其达到与收缩期相似的水平。还研究了缝线位置和延伸以及二尖瓣环尺寸的影响。结果表明，无论是在瓣膜功能（压力水平和活动性）还是在内部应力水平方面，缝线的侧向位置均优于中心位置，较长的缝线可增强瓣膜功能，但可降低应力水平，最后，二尖瓣环扩张不会影响瓣膜功能，但会增加应力水平。(c)2004爱思唯尔有限公司保留所有权利。
The structural and functional effects of the "edge-to-edge" technique on the human mitral valve have been investigated, paying particular attention to the diastolic phase. An advanced finite element model of the valve has been developed, using a hyperelastic material schematization, suitable geometry and constraint conditions, and an effective fluidodynamic analysis. The edge-to-edge suture has been applied on this model and the diastolic phase has been simulated. The results of this calculation show that the operation increases the transvalvular pressure and the maximum stress in the leaflets, which reaches a level similar to that of the systolic phase. The influence of suture position and extension, and the mitral annulus dimension has also been investigated. The results indicate that a lateral location of the stitch is better than a central one, both regarding valve functionality (pressure level and mobility) and internal stresses level, that a longer suture worsens the valve functionality but reduces the stresses level, finally, that the dilatation of the mitral annulus does not affect the valve functionality but increases the stresses level. (c) 2004 Elsevier Ltd. All rights reserved.